Results 91 to 100 of about 390,411 (306)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Insights into Chemical Bonds for Eliminating the Depletion Region and Accelerating the Photo-Induced Charge Efficient Separation toward Ultrasensitive Photoelectrochemical Sensing. [PDF]
Biosensors (Basel), 2023 Wang S, Yu H, Ge S, Wang Y, Gao C, Yu J.
europepmc +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Meta-analysis of depleted uranium levels in the Middle East region
Journal of Environmental Radioactivity, 2018 Since the first widespread use of depleted uranium in military in the 1991 Gulf War, the so-called "Gulf War Syndrome" has been a topic of ongoing debate. However, a low number of reliable scientific papers demonstrating the extent of possible contamination as well as its connection to the health status of residents and deployed veterans has been ...
Larisa Bešić +5 more
openaire +3 more sources
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Photothermal microscopy of silicon epitaxial layer on silicon substrate with depletion region at the interface [PDF]
, 2003 Photothermal microscopy has been used for investigating semiconductor materials to evaluate carrier diffusivity, lifetime, and surface recombination velocity.
7356 +8 more
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
An empirical analysis of groundwater depletion in the High Plains-Ogallala Aquifer region [PDF]
Master of ArtsDepartment of Sociology, Anthropology, and Social WorkMatthew R. SandersonDepletion of the Ogallala Aquifer is a significant concern for many communities in the High Plains region and, indeed, the global food system.
Hughes, Maria Vivian
core
, 2009 A technique for the reduction in Shockley–Read–Hall recombination in semiconductor diodes, in which areas of the depletion region are removed, is described and preliminary results obtained using AlInSb light-emitting-diodes (LEDs) are presented. Both the
T. Ashley +3 more
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source