Results 71 to 80 of about 390,411 (306)
BMC Genomics, 2020 Background There are challenges in generating mRNA-Seq data from whole-blood derived RNA as globin gene and rRNA are frequent contaminants. Given the abundance of erythrocytes in whole blood, globin genes comprise some 80% or more of the total RNA ...
Jin Sung Jang +7 more
doaj +1 more source
Sex- and region-biased depletion of microglia/macrophages attenuates CLN1 disease in mice
Journal of Neuroinflammation, 2020 Background The neuronal ceroid lipofuscinoses (CLN diseases) are fatal lysosomal storage diseases causing neurodegeneration in the CNS. We have previously shown that neuroinflammation comprising innate and adaptive immune reactions drives axonal damage ...
Kristina Berve +3 more
doaj +1 more source
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
IQGAP1 functions as a modulator of dishevelled nuclear localization in Wnt signaling. [PDF]
PLoS ONE, 2013 Dishevelled (DVL) is a central factor in the Wnt signaling pathway, which is highly conserved among various organisms. DVL plays important roles in transcriptional activation in the nucleus, but the molecular mechanisms underlying their nuclear ...
Toshiyasu Goto +7 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Geophysical Research LettersThe development of an intense total electron content (TEC) depletion band over the United States during the 8 September 2017 geomagnetic storm was understood as the extension of an equatorial plasma bubble (EPB) to midlatitudes in previous studies ...
Hyosub Kil +4 more
doaj +1 more source
Observed and simulated depletion layers with southward IMF [PDF]
Annales Geophysicae, 2004 We present observations from the Polar satellite that confirm the existence of two types of depletion layers predicted under southward interplanetary magnetic field (IMF) conditions in magnetohydrodynamic simulations.
N. C. Maynard +10 more
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Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Magnetospheric signatures of ionospheric density cavities observed by Cluster [PDF]
, 2015 AJBR ackowledges support from STFC under consolidated grant ST/K000993/1.We present Cluster measurements of large amplitude electric fields corre- lated with intense downward field-aligned currents, observed during a nightside crossing of the auroral ...
Wright, A. N. +9 more
core +1 more source
Charging mechanism of electret film made of potassium-ion-doped SiO2
AIP Advances, 2016 A charging model is proposed for an electret film made of potassium-ion-doped SiO2 that can be formed between the two opposing micro-electrodes of a micro-electrostatic actuator, separated by a microscopic gap.
G. Hashiguchi +4 more
doaj +1 more source