Results 111 to 120 of about 6,149,007 (323)

Nitrogen isotopic ratios in Barnard 1: a consistent study of the N2H+, NH3, CN, HCN and HNC isotopologues

, 2013
The 15N isotopologue abundance ratio measured today in different bodies of the solar system is thought to be connected to 15N-fractionation effects that would have occured in the protosolar nebula.
Biver, N., Bockelee--Morvan, D., Cernicharo, J., Daniel, F., Gerin, M., Lique, F., Lis, D. C., Marcelino, N., Roueff, E., Teyssier, D.   +9 more
core   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Facile fabrication of lateral nanowire wrap-gate devices with improved performance

, 2011
We present a simple fabrication technique for lateral nanowire wrap-gate devices with high capacitive coupling and field-effect mobility. Our process uses e-beam lithography with a single resist-spinning step, and does not require chemical etching.
Bhattacharya, Arnab, Deshmukh, Mandar M., Dhara, Sajal, Gokhale, M. R., Maurya, Arvind, R., Arvind Pavan, Sengupta, Shamashis, Solanki, Hari S.   +7 more
core   +1 more source

Groundwater depletion in the Middle East from GRACE with implications for transboundary water management in the Tigris-Euphrates-Western Iran region

Water Resources Research, 2013
In this study, we use observations from the Gravity Recovery and Climate Experiment (GRACE) satellite mission to evaluate freshwater storage trends in the north‐central Middle East, including portions of the Tigris and Euphrates River Basins and western ...
K. Voss, J. Famiglietti, M. Lo, C. Linage, M. Rodell, S. Swenson   +5 more
semanticscholar   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Depletion of CBP is directly linked with cellular toxicity caused by mutant huntingtin

Neurobiology of Disease, 2006
Huntington's disease is a neurodegenerative disease caused by an expanded polyglutamine stretch within the huntingtin protein. Transfection of mutant huntingtin causes cell toxicity and depletion of CREB binding protein (CBP) or its recruitment into ...
Haibing Jiang, Michelle A. Poirier, Yideng Liang, Zhong Pei, Charlotte E. Weiskittel, Wanli W. Smith, Donald B. DeFranco, Christopher A. Ross   +7 more
doaj   +1 more source

The Mg II 2797, 2803 emission in low-metallicity star-forming galaxies from the SDSS

, 2013
We present 65 Sloan Digital Sky Survey (SDSS) spectra of 62 star-forming galaxies with oxygen abundances 12 + logO/H ~ 7.5-8.4. Redshifts of selected galaxies are in the range z~0.36-0.70.
Fricke, K. J., Guseva, N. G., Henkel, C., Izotov, Y. I.   +3 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Effect of Sintering Time on the Densification, Microstructure, Weight Loss and Tensile Properties of a Powder Metallurgical Fe-Mn-Si Alloy

Metals, 2017
This work investigated the isothermal holding time dependence of the densification, microstructure, weight loss, and tensile properties of Fe-Mn-Si powder compacts.
Zhigang Xu, Michael A. Hodgson, Keke Chang, Gang Chen, Xiaowen Yuan, Peng Cao   +5 more
doaj   +1 more source