Advanced Science, EarlyView.Lipid metabolic stress triggers ferroptosis in PDLSCs through the GSK3β/NRF2 pathway, thereby aggravating periodontal bone loss. Upregulated GSK3β promotes NRF2 ubiquitination and proteasomal degradation via β‐TrCP, suppressing NRF2 nuclear translocation and antioxidant target expression.
Yuxiao Zhang +11 more
wiley +1 more source
Advanced Science, EarlyView.A mechanically interlocked polyrotaxane hydrogel integrates sliding macrocycles within a covalent network, yielding skin‑like softness, high stretchability, robust adhesion, and stable ionic conductivity. This multifunctional interface enables simultaneous high‑fidelity monitoring of human motion and epidermal electrophysiological signals (ECG/EMG ...
Hao‐Zheng Huang +9 more
wiley +1 more source
Depolarization of μ〓 Meson in Silicon
, 2010 Depolarization of μ^+ meson in silicon is considered. Depolarization observed by FEHER et al. is analyzed from the standpoint of a deep trap model of muoniums. The hyperfine separation of muonium binding energy ΔE/ћ=8.0x10^9 sec^ and σ_=3.9x10^ cm^2.Tese
NAGATA, Shozo
core
Advanced Science, EarlyView.The study elucidates that paternal preconception stress can drive offspring hyperresponsivity of the stress system via hypomethylation of a specific DNA region in sperm. This key link is confirmed in a cohort of prospective fathers: the epigenetic alteration is associated with elevated stress hormone levels.
Mengxi Lu +10 more
wiley +1 more source
Electrophysiological Markers in Hypertrophic Cardiomyopathy: Enhancing Sudden Cardiac Death Risk Prediction with Index of Cardiac Electrophysiological Balance and Its Corrected Variant. [PDF]
Anatol J CardiolBalaban İ +7 more
europepmc +1 more source
Localizable Fluorescent Metal Ion Indicators With Tunable Colors
Advanced Science, EarlyView.A modular platform enables the generation of fluorescent metal ion indicators with tunable emission colors and precise subcellular localization. Conjugation to self‐labeling proteins yields bright, color‐tunable potassium probes that permit wash‐free live‐cell imaging, revealing dynamic potassium efflux in stimulated neurons.
Ming‐Ming Wang +3 more
wiley +1 more source
TTX-S/TTX-R Na<sup>+</sup> Currents Coordinately Fine-Tune Depolarization/Firing Capability Revealed by Voltage Derivatives/Displacement Current Phase Plots With Dynamic Current-Clamp Simulation in Rat Visceral Sensory Neurons. [PDF]
Acta Physiol (Oxf)Jing-Ran Z +6 more
europepmc +1 more source
Self‐Accelerating Bimetallic Peroxide Nanozymes for Cascade‐Amplified Pyroptosis‐Immunotherapy
Advanced Science, EarlyView.Acidic tumor microenvironment‐responsive CuZnONPs enable triple‐combination therapy via self‐supplying H2O2, cascade nanozyme activities for ROS burst, and Zn2+‐activated pyroptosis, synergizing catalytic therapy with immunotherapy to convert cold tumors into hot ones.
Xuanyi Lu +9 more
wiley +1 more source
Distinct Effects of Nonselective Rho-Kinase Inhibitor Fasudil and Selective Rho-Kinase 2 Inhibitor KD025 on Serotonin and Dopamine Release in the Nucleus Accumbens of Mice. [PDF]
Neuropsychopharmacol RepTanaka R +8 more
europepmc +1 more source
Advanced Science, EarlyView.NET‐DNA is enriched during early endometriotic lesion establishment and drives anoikis resistance by promoting an ANXA2–TMEM215–BiP axis. This pathway strengthens ER–mitochondria contacts, enhances PINK1/Parkin‐associated mitophagy, preserves mitochondrial homeostasis, and supports ectopic stromal cell survival, thereby facilitating lesion persistence ...
Honglin Wang +12 more
wiley +1 more source