Results 191 to 200 of about 254,537 (363)

CXCL13 Damages Blood Spinal Cord Barrier by Promoting RNF6/Sqstm1‐Ubiquitination Induced Autophagy in Experimental Allergic Encephalomyelitis

open access: yesAdvanced Science, EarlyView.
In multiple sclerosis, the disruption of the blood‐spinal cord barrier (BSCB) induced by CXCL13 facilitates the infiltration of inflammatory cells into the central nervous system, resulting in demyelination and neuronal injury. Mechanistically, the deleterious impact of CXCL13 on the BSCB is associated with a reduction in tight junction protein ...
Jingjing Han   +10 more
wiley   +1 more source

Autophagy Related 5 Promotes Mitochondrial Fission and Inflammation via HSP90‐HIF‐1α‐Mediated Glycolysis in Kidney Fibrosis

open access: yesAdvanced Science, EarlyView.
When the normal kidney is subjected to injurious stimuli, it can lead to persistent activation of ATG5. The activation of ATG5 promotes HSP90‐HIF‐1α interaction, resulting in stabilization of HIF‐1α and subsequent activation of glycolysis. Consequently, this process contributes to mitochondrial fission and inflammation, ultimately culminating in kidney
Yan Hu   +11 more
wiley   +1 more source

Syntaxin 17 Translocation Mediated Mitophagy Switching Drives Hyperglycemia‐Induced Vascular Injury

open access: yesAdvanced Science, EarlyView.
Mitophagy switching drives high‐glucose‐induced vascular endothelial injury. Short‐term high‐glucose exposure upregulates Fis1 expression and enhances Fis1‐TBC1D15 interaction, activating Parkin‐mediated mitophagy. Long‐term high‐glucose exposure reduces Fis1 expression, inhibiting Parkin‐mediated mitophagy and triggering mitophagy switching from ...
Anqi Luo   +10 more
wiley   +1 more source

Multi‐Shank 1024 Channels Active SiNAPS Probe for Large Multi‐Regional Topographical Electrophysiological Mapping of Neural Dynamics

open access: yesAdvanced Science, EarlyView.
This research article introduces a novel CMOS neural probe with 1024 channels distributed across eight shanks. The SiNAPS probe allows for the simultaneous recording of both local field potentials and action potentials in large brain areas. The probe's design allows for detailed mapping and linking neural dynamics and population unit activity, as ...
Gian Nicola Angotzi   +13 more
wiley   +1 more source

Boosting environmental management: The mediating role of Industry 4.0 between environmental assets and economic and social firm performance

open access: yesBusiness Strategy and the Environment, Volume 32, Issue 1, Page 753-768, January 2023., 2023
Abstract The adoption of new innovative ecosystems linked to Industry 4.0 (I4.0) in industrial firms has created new opportunities for performance. In this study, we investigate whether I4.0 can reinforce environmental asset management in achieving firm economic and social performance. We intend to contrast the existence of I4.0‐based reward mechanisms
Joan Torrent‐Sellens   +2 more
wiley   +1 more source

NOREPINEPHRINE-INDUCED DEPOLARIZATION OF BROWN FAT CELLS [PDF]

open access: green, 1969
Barbara A. Horwitz   +2 more
openalex   +1 more source

Electroactive Electrospun Nanofibrous Scaffolds: Innovative Approaches for Improved Skin Wound Healing

open access: yesAdvanced Science, EarlyView.
This review explores the potential of electroactive electrospun nanofibrous (EEN) scaffolds for enhanced skin wound healing. It discusses how a variety of electroactive materials can be prepared into EEN scaffolds via electrospinning technology, and their applications in various wound types. The review provides insights into the future perspectives for
Yang Zhang   +10 more
wiley   +1 more source

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