Results 61 to 70 of about 1,453,523 (291)

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Mineralization, geochemistry, fluid inclusion and sulfur stable isotope studies in the carbonate hosted Baqoroq Cu-Zn-As deposit (NE Anarak)

Journal of Economic Geology, 2015
Introduction The Baqoroq Cu-Zn-As deposit is located northeast of the town ofAnarak in Isfahan province, in theeast central areaof Iran. Copper mineralization occursin upper cretaceous carbonate rocks.Studyof thegeologyof the Nakhlak area, the ...
Mohammad Ali Jazi, Mohammad Hassan Karimpour, Azadeh Malekzadeh Shafaroudi   +2 more
doaj  

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Geographic deposit competition [PDF]

Bank competition ; Banking market ; Money market deposit account ; California ; Banks and banking ...
Gary C. Zimmerman, Michael C. Keeley
core  

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Progress of in situ U-Th/He Isotopic Dating Technique and Its Application to Low Temperature Deposits

Yankuang ceshi, 2017
The traditional single-grain U-Th/He isotopic dating method a uses time-consuming acid dissolution, correction for α-ejection and more requirements on target minerals (euhedral, transparent, no cracks or inclusions).
FU Shan-ling, ZHAO Cheng-hai
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Chemical Pre-treatment Methods for Measurement of Ge Isotopic Ratio on Sphalerite in Lead-Zinc Deposits

Yankuang ceshi, 2014
Up to the present, main research of Ge isotopes has been carried out on organic, magmatic and meteoritic samples. Pb-Zn deposits are one of the most important reservoirs of Ge; however, there are few studies on Ge isotopes for these samples.
ZHU Chuan-wei, WEN Han-jie, FAN Hai-feng, ZHANG Yu-xu, LIU Jie, YANG Tao, WANG Guang-hui   +6 more
doaj   +2 more sources

Probing the surface electrical properties of clay minerals with electrostatic force microscopy and kelvin probe force microscopy

Materials Research Express
Many surface processes of clay minerals require in-depth understanding of their surface electrical properties, such as surface charge density, surface potential distribution, etc In this paper, electrostatic force microscopy (EFM) and Kelvin probe force ...
Zonghua Qin, Xin Nie, Wenbin Yu, Shuguang Yang, Zongke Zhou, Shuqin Yang, Quan Wan   +6 more
doaj   +1 more source