Results 71 to 80 of about 222,830 (268)

Housing Affordability: Local and National Perspectives

International Journal of Population Data Science, 2018
This paper presents a new approach to measuring affordable homeownership. Future changes in the homeownership rate will depend on the ability of today’s renters to become homeowners.
Laurie Goodman, Wei Li, Jun Zhu
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Understanding the relationship between pore size, surface charge density, and Cu2+ adsorption in mesoporous silica

Scientific Reports
This research delved into the influence of mesoporous silica’s surface charge density on the adsorption of Cu2+. The synthesis of mesoporous silica employed the hydrothermal method, with pore size controlled by varying the length of trimethylammonium ...
Yanhui Niu, Wenbin Yu, Shuguang Yang, Quan Wan   +3 more
doaj   +1 more source

Integrated Mine Geophysics for Identifying Zones of Geological Instability

Applied Sciences
The safety and stability of underground coal mining are largely determined by the structural features of coal seams and surrounding rocks. Geological heterogeneities such as faults, fracture zones, and lithological variations strongly influence the ...
Nail Zamaliyev, Alexander Sadchikov, Denis Akhmatnurov, Ravil Mussin, Krzysztof Skrzypkowski, Nikita Ganyukov, Nazym Issina   +6 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

U-Pb zircon geochronology, Sr-Nd isotope geochemistry, and petrogenesis of oxidant granitoids at Keybarkuh, southwest of Khaf

Journal of Economic Geology, 2012
Keybarkuh area is located 70 km southwest of Khaf, Khorasan Razavi province. The study area is situated in northeastern Lut block. The rock units in the area are Paleozoic metamorphic rocks and Cretaceous to Tertiary subvolcanic intrusions intruded as ...
Ehsan Salati, Mohammad Hassan Karimpour, Azadeh Malekzadeh Shafaroudi, Mohammad Reza Hydarian Shahri, Lang Farmer, Chuck Stern   +5 more
doaj  

Assessment of Strength Characteristics and Structural Heterogeneity of Coal Seams in the Karaganda Basin by Geophysical Methods for Enhancing Mining Safety

Mining
The principal difficulty in studying the physico-mechanical and filtration-capacity properties of coals and host rocks under laboratory conditions using core samples lies in reproducing natural thermodynamic conditions characteristic of in situ depths ...
Ravil Mussin, Vassiliy Portnov, Andrey Golik, Nail Zamaliyev, Denis Akhmatnurov, Nikita Ganyukov, Krzysztof Skrzypkowski, Krzysztof Zagórski, Svetlana Efremova   +8 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Geological Controls on Natural Pre-Concentration in Mineral Deposits: Case Study of Gramalote and Telfer West Dome

Geosciences
The preferential concentration of metals into finer size fractions (
Nathaly Guerrero, Julie Hunt, Matthew J. Cracknell, Luke Keeney   +3 more
doaj   +1 more source