Results 71 to 80 of about 230,700 (268)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Machine-learning crystal size distribution for volcanic stratigraphy correlation

Scientific Reports
Volcanic stratigraphy reconstruction is traditionally based on qualitative facies analysis complemented by geochemical analyses. Here we present a novel technique based on machine learning identification of crystal size distribution to quantitatively ...
Martin Jutzeler, Rebecca J. Carey, Yasin Dagasan, Andrew McNeill, Ray A. F. Cas   +4 more
doaj   +1 more source

Housing Affordability: Local and National Perspectives

International Journal of Population Data Science, 2018
This paper presents a new approach to measuring affordable homeownership. Future changes in the homeownership rate will depend on the ability of today’s renters to become homeowners.
Laurie Goodman, Wei Li, Jun Zhu
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Understanding the relationship between pore size, surface charge density, and Cu2+ adsorption in mesoporous silica

Scientific Reports
This research delved into the influence of mesoporous silica’s surface charge density on the adsorption of Cu2+. The synthesis of mesoporous silica employed the hydrothermal method, with pore size controlled by varying the length of trimethylammonium ...
Yanhui Niu, Wenbin Yu, Shuguang Yang, Quan Wan   +3 more
doaj   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

U-Pb zircon geochronology, Sr-Nd isotope geochemistry, and petrogenesis of oxidant granitoids at Keybarkuh, southwest of Khaf

Journal of Economic Geology, 2012
Keybarkuh area is located 70 km southwest of Khaf, Khorasan Razavi province. The study area is situated in northeastern Lut block. The rock units in the area are Paleozoic metamorphic rocks and Cretaceous to Tertiary subvolcanic intrusions intruded as ...
Ehsan Salati, Mohammad Hassan Karimpour, Azadeh Malekzadeh Shafaroudi, Mohammad Reza Hydarian Shahri, Lang Farmer, Chuck Stern   +5 more
doaj  

Assessment of Strength Characteristics and Structural Heterogeneity of Coal Seams in the Karaganda Basin by Geophysical Methods for Enhancing Mining Safety

Mining
The principal difficulty in studying the physico-mechanical and filtration-capacity properties of coals and host rocks under laboratory conditions using core samples lies in reproducing natural thermodynamic conditions characteristic of in situ depths ...
Ravil Mussin, Vassiliy Portnov, Andrey Golik, Nail Zamaliyev, Denis Akhmatnurov, Nikita Ganyukov, Krzysztof Skrzypkowski, Krzysztof Zagórski, Svetlana Efremova   +8 more
doaj   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source