Results 91 to 100 of about 462,800 (317)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

MODIS: A Market-Oriented Deposit Insurance Scheme [PDF]

open access: yes
This paper argues that an optimal deposit insurance scheme would allow the level of insurance coverage to be determined by the market. Based on this principle, the paper proposes an insurance scheme that minimizes distortions and embodies fairness and ...
Danyang Xie, Edda Zoli, Reza Vaez-Zadeh
core  

Understanding the relationship between pore size, surface charge density, and Cu2+ adsorption in mesoporous silica

open access: yesScientific Reports
This research delved into the influence of mesoporous silica’s surface charge density on the adsorption of Cu2+. The synthesis of mesoporous silica employed the hydrothermal method, with pore size controlled by varying the length of trimethylammonium ...
Yanhui Niu   +3 more
doaj   +1 more source

Integrated Mine Geophysics for Identifying Zones of Geological Instability

open access: yesApplied Sciences
The safety and stability of underground coal mining are largely determined by the structural features of coal seams and surrounding rocks. Geological heterogeneities such as faults, fracture zones, and lithological variations strongly influence the ...
Nail Zamaliyev   +6 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

Deregulation and deposit insurance reform [PDF]

open access: yes
Deposit insurance ; Bank supervision ...
David Pyle
core  

Software Deposit: What To Deposit

open access: yes, 2018
What do we mean by a "software deposit"? What does a software deposit need to contain to enable it to allow other researchers to inspect, replicate, reproduce and reuse the research, as manifested in the software, in the short term and inspect the software, for the historical record, in the long term. This guide describes what a software deposit should
openaire   +2 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

The political economy of deposit insurance [PDF]

open access: yes
The author uses a political economy framework to analyze cross-country differences in deposit insurance coverage. He finds supporting evidence of the significance of private interest theories in explaining coverage of deposit insurance. Deposit insurance
Laeven, Luc
core  

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