Results 41 to 50 of about 4,466,202 (380)

Speciation Through the Lens of Population Dynamics: A Theoretical Primer on How Small and Large Populations Diverge

Population Ecology, EarlyView.
Population size and dynamics fundamentally shape speciation by influencing genetic drift, founder events, and adaptive potential. Small populations may speciate rapidly due to stronger drift, whereas large populations harbor more genetic diversity, which can alter divergence trajectories. We highlight theoretical models that incorporate population size
Ryo Yamaguchi, Hidaka Kubo, Tokuya Ogawa, Hayate Omura   +3 more
wiley   +1 more source

Depression [PDF]

Annals of Internal Medicine, 2016
This issue provides a clinical overview of depression, focusing on screening, diagnosis, treatment, and practice improvement. The content of In the Clinic is drawn from the clinical information and education resources of the American College of Physicians (ACP), including MKSAP (Medical Knowledge and Self-Assessment Program).
Robert M, McCarron, Erik R, Vanderlip, Jeffrey, Rado   +2 more
openaire   +4 more sources

Depression and quality of life in patients with type 2 diabetes [PDF]

, 2015
Background: Frequency of mood disorders in patients with chronic diseases, especially diabetes and its effects on life quality are dramatically increasing. Objectives: This study aimed to investigate the relation between depression and quality of life in
Derakhshanpour, F., Farsinia, M., Mirkarimi, K., Vakili, M.A.   +3 more
core   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Re-work Program in Japan—Overview and Outcome of the Program

Frontiers in Psychiatry, 2021
Background: The objective of this study was to examine the effect of the Japanese re-work program (RP) to aid in recurrent sick leave prevention.Methods: A multicenter retrospective cohort research was conducted for workers who returned to work (RTW ...
Yoko Ohki, Yoko Ohki, Yoshio Igarashi, Yoshio Igarashi, Yoshio Igarashi, Keita Yamauchi   +5 more
doaj   +1 more source

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Traumatic stress alters neural reactivity to visual stimulation

NPP-Digital Psychiatry and Neuroscience
Traumatic stress is a precursor to the development of posttraumatic stress disorder (PTSD). Emergent research suggests visual processing regions may be relevant to PTSD development; however, no previous research to date has investigated the potential ...
Nathaniel G. Harnett, Grace E. Rowland, E. Kate Webb, Tianyi Li, Soumyaa Joshi, Kerry J. Ressler, Isabelle M. Rosso   +6 more
doaj   +1 more source

Disclosure of Depression in Primary Care: A Qualitative Study of Women’s Perceptions [PDF]

, 2016
Background Health care providers are better able to diagnose depression and initiate treatment when patients disclose symptoms. However, many women are reluctant to disclose depressive symptoms.
Jacobs, Elizabeth A., Keller, Abiola O., Schwei, Rebecca J., Valdez, Carmen R.   +3 more
core   +2 more sources

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

Nature Genetics, 2017
Major depressive disorder (MDD) is a common illness accompanied by considerable morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide association meta-analysis based in 135,458 cases and 344,901 controls and identified ...
N. Wray, S. Ripke, M. Mattheisen, M. Trzaskowski, Enda M. Byrne, A. Abdellaoui, Mark J Adams, E. Agerbo, T. Air, Till F. M. Andlauer, S. Bacanu, Marie Bækvad-Hansen, A. Beekman, T. Bigdeli, E. Binder, D. Blackwood, J. Bryois, H. Buttenschøn, J. Bybjerg-Grauholm, N. Cai, E. Castelao, J. Christensen, Toni‐Kim Clarke, Jonathan R. I. Coleman, L. Colodro-Conde, B. Couvy-Duchesne, N. Craddock, Gregory E. Crawford, Cheynna A. Crowley, Hassan S. Dashti, G. Davies, I. Deary, F. Degenhardt, E. Derks, N. Direk, Conor V. Dolan, Erin C. Dunn, T. Eley, N. Eriksson, V. Escott-Price, Farnush Farhadi Hassan Kiadeh, H. Finucane, A. Forstner, J. Frank, Héléna A. Gaspar, M. Gill, P. Giusti-Rodríguez, F. Goes, Scott D. Gordon, J. Grove, L. Hall, E. Hannon, C. Hansen, Thomas F. Hansen, S. Herms, Ian B. Hickie, P. Hoffmann, G. Homuth, Carsten Horn, J. Hottenga, D. Hougaard, Ming Hu, Craig L Hyde, M. Ising, R. Jansen, Fulai Jin, E. Jorgenson, J. A. Knowles, Isaac S. Kohane, J. Kraft, Warren W. Kretzschmar, J. Krogh, Z. Kutalik, J. Lane, Yihan Li, Yun Li, P. Lind, Xiaoxiao Liu, Leina Lu, D. Macintyre, D. MacKinnon, Robert M. Maier, W. Maier, J. Marchini, H. Mbarek, P. McGrath, P. McGuffin, S. Medland, D. Mehta, C. Middeldorp, E. Mihailov, Y. Milaneschi, L. Milani, J. Mill, Francis M. Mondimore, Grant W. Montgomery, S. Mostafavi, N. Mullins, M. Nauck, B. Ng, M. Nivard, D. Nyholt, Paul F. O’Reilly, H. Oskarsson, Michael J. Owen, J. Painter, C. B. Pedersen, M. Pedersen, Roseann E. Peterson, E. Pettersson, W. Peyrot, G. Pistis, D. Posthuma, Shaun Purcell, Jorge A. Quiroz, P. Qvist, John P. Rice, B. Riley, M. Rivera, Saira Saeed Mirza, R. Saxena, R. Schoevers, E. Schulte, L. Shen, Jianxin Shi, Stanley I. Shyn, E. Sigurdsson, Grant C. B. Sinnamon, Johannes H. Smit, Daniel J. Smith, H. Stefánsson, S. Steinberg, C. Stockmeier, F. Streit, J. Strohmaier, K. Tansey, H. Teismann, A. Teumer, W. Thompson, P. Thomson, T. Thorgeirsson, C. Tian, M. Traylor, J. Treutlein, V. Trubetskoy, A. Uitterlinden, D. Umbricht, S. Van der Auwera, A. V. van Hemert, A. Viktorin, P. M. Visscher, Yunpeng Wang, B. Webb, S. Weinsheimer, J. Wellmann, G. Willemsen, S. Witt, Yang Wu, H. Xi, Jian Yang, Futao Zhang, V. Arolt, Bernhard T. Baune, K. Berger, D. Boomsma, S. Cichon, U. Dannlowski, E. D. de Geus, J. DePaulo, E. Domenici, K. Domschke, T. Esko, H. Grabe, S. Hamilton, C. Hayward, A. C. Heath, D. Hinds, K. Kendler, S. Kloiber, G. Lewis, Qingqin S Li, S. Lucae, P. Madden, Patrik K. E. Magnusson, Nicholas G. Martin, Andrew M. McIntosh, A. Metspalu, O. Mors, P. Mortensen, B. Müller-Myhsok, M. Nordentoft, M. Nöthen, M. O’Donovan, S. Paciga, Nancy L Pedersen, B. Penninx, R. Perlis, D. Porteous, J. Potash, M. Preisig, M. Rietschel, C. Schaefer, T. G. Schulze, J. Smoller, K. Stefánsson, H. Tiemeier, R. Uher, H. Völzke, Myrna M Weissman, T. Werge, Ashley R. Winslow, C. Lewis, D. Levinson, G. Breen, A. Børglum, P. Sullivan   +215 more
semanticscholar   +1 more source

The serotonin theory of depression: a systematic umbrella review of the evidence

Molecular Psychiatry, 2022
The serotonin hypothesis of depression is still influential. We aimed to synthesise and evaluate evidence on whether depression is associated with lowered serotonin concentration or activity in a systematic umbrella review of the principal relevant areas
J. Moncrieff, R. Cooper, Tom Stockmann, Simone Amendola, M. Hengartner, M. Horowitz   +5 more
semanticscholar   +1 more source