Results 51 to 60 of about 3,653,977 (340)

Using Drift Diffusion and RL Models to Disentangle Effects of Depression On Decision-Making vs. Learning in the Probabilistic Reward Task

Computational Psychiatry
The Probabilistic Reward Task (PRT) is widely used to investigate the impact of Major Depressive Disorder (MDD) on reinforcement learning (RL), and recent studies have used it to provide insight into decision-making mechanisms affected by MDD.
Daniel G. Dillon, Emily L. Belleau, Julianne Origlio, Madison McKee, Aava Jahan, Ashley Meyer, Min Kang Souther, Devon Brunner, Manuel Kuhn, Yuen Siang Ang, Cristina Cusin, Maurizio Fava, Diego A. Pizzagalli   +12 more
doaj   +1 more source

The importance of both setting and intensity of physical activity in relation to non-clinical anxiety and depression [PDF]

, 2007
Physical activity is associated with good physical and mental health. Current recommendations suggest that people should achieve 30 minutes of moderate-intensity activity most days of the week to gain health benefits.
Bernaards C M, Biddle S JH, Biddle S JH, Camacho T C, Clark A, Cooper-Patrick L, Department of Health, Der G, Dong W, Dunn A, Dunn A L, Ecob R, Farmer M, Goldberg D P, Kearney J M, Kritz-Silverstein D, Lawlor D A, Lawlor D A, Macintyre S, Mobily K E, Moses J, Moti R W, Mutrie N, OPCS, Paffenbarger R S, Pate R R, Schnohr P, Seligman M EP, Snaith R P, Strawbridge W J, Thorsen L, US Department of Health and Human Services, Van Gool C H, Weyerer S, World Health Organisation   +34 more
core   +2 more sources

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Poverty, Maternal Depression, Family Status and Children's Cognitive and Behavioural Development in Early Childhood: A Longitudinal Study [PDF]

, 2009
Improving children's lives is high on the UK policy agenda. In this study for a recent birth cohort of UK children we examine how three aspects of parental resources - income, mother's mental well-being and family status - in early childhood enhance or ...
Kiernan, Kathleen E., Mensah, Fiona K.
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Neural and behavioral markers of inhibitory control predict symptom improvement during internet-delivered cognitive behavioral therapy for depression

Translational Psychiatry
Poor inhibitory control contributes to deficits in emotion regulation, which are often targeted by treatments for major depressive disorder (MDD), including cognitive behavioral therapy (CBT).
Michelle Thai, Elizabeth A. Olson, Stefanie Nickels, Daniel G. Dillon, Christian A. Webb, Boyu Ren, William D. S. Killgore, Scott L. Rauch, Isabelle M. Rosso, Diego A. Pizzagalli   +9 more
doaj   +1 more source

Therapeutic alliance in the initial phase of psychotherapy with adolescents: different perspectives and their association with therapeutic outcomes

Research in Psychotherapy, 2016
Psychotherapy research focusing on adults as well as on children and adolescents has revealed a positive association between the quality of the therapeutic alliance (TA) in the first sessions and therapeutic outcomes.
Olga María Fernandez, Mariane Krause, Janet Carola Pérez   +2 more
doaj   +1 more source

Lithium augmentation of ketamine increases insulin signaling and antidepressant-like active stress coping in a rodent model of treatment-resistant depression

Translational Psychiatry, 2021
Lithium, a mood stabilizer and common adjunctive treatment for refractory depression, shares overlapping mechanisms of action with ketamine and enhances the duration of ketamine’s antidepressant actions in rodent models at sub-therapeutic doses.
J. Blair Price, Clarissa G. Yates, Brooke A. Morath, Sam K. Van De Wakker, Nathanael J. Yates, Kim Butters, Mark A. Frye, Sean L. McGee, Susannah J. Tye   +8 more
doaj   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Development, reach, acceptability and associated clinical changes of a group intervention to improve caregiver‐adolescent relationships in the context of adolescent depression

JCPP Advances, 2023
Background Adolescents with depression often experience relationship problems with their caregivers, which predict poorer treatment outcomes. Personalising interventions by targeting factors associated with poor treatment outcomes may enhance the ...
Madison Aitken, Ameeta Sagar, Darren Courtney, Peter Szatmari   +3 more
doaj   +1 more source