Results 11 to 20 of about 786,893 (341)
Major depressive disorder [PDF]
Nature Reviews Disease Primers, 2016 Major depressive disorder (MDD) is a debilitating disease that is characterized by depressed mood, diminished interests, impaired cognitive function and vegetative symptoms, such as disturbed sleep or appetite. MDD occurs about twice as often in women than it does in men and affects one in six adults in their lifetime.
Stefan M. Gold +8 more
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Perfectionism in Major Depressive Disorder [PDF]
Psikiyatride Güncel Yaklaşımlar, 2020 Perfectionism is individuals setting hard-to-reach goals for themselves or others and striving to achieve them. People have difficulties in their lives because of their perfectionist thinking.
Gülen Say
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The Economic Burden of Adults with Major Depressive Disorder in the United States (2010 and 2018)
PharmacoEconomics (Auckland), 2021 The incremental economic burden of US adults with major depressive disorder (MDD) was estimated at $US210.5 billion in 2010 (year 2012 values). Following a similar methodology, this study updates the previous findings with more recent data to report the ...
P. Greenberg +6 more
semanticscholar +1 more source
Single-Dose Psilocybin Treatment for Major Depressive Disorder: A Randomized Clinical Trial.
Journal of the American Medical Association (JAMA), 2023 Importance Psilocybin shows promise as a treatment for major depressive disorder (MDD). Objective To evaluate the magnitude, timing, and durability of antidepressant effects and safety of a single dose of psilocybin in patients with MDD.
C. Raison +33 more
semanticscholar +1 more source
Efficacy of Ketamine as an Adjuvant to Antidepressants in the Treatment of Depression [PDF]
Journal of Clinical and Diagnostic Research, 2021 Introduction: Depression is the second leading cause of morbidity worldwide. Currently, available antidepressants mostly target the monoamine system. The onset of action and response rates for these antidepressants are varied.
Hrishikesh Solunke +4 more
doaj +1 more source
Major Depressive Disorder [PDF]
Neuron, 2000 In summary, MDD is a highly prevalent major medical whose pathophysiology is still poorly understood. MDD is often recurrent or chronic, and evidence suggests that genetic factors partially influence overall risk of illness but also influence the sensitivity of individuals to the depressogenic effects of environmental adversity.
Maurizio Fava, Kenneth S. Kendler
openaire +2 more sources
Molecular Psychiatry, 2022 The emerging understanding of gut microbiota as ‘metabolic machinery’ influencing many aspects of physiology has gained substantial attention in the field of psychiatry. This is largely due to the many overlapping pathophysiological mechanisms associated
A. McGuinness +15 more
semanticscholar +1 more source
Molecular pathways of major depressive disorder converge on the synapse
Molecular Psychiatry, 2022 Major depressive disorder (MDD) is a psychiatric disease of still poorly understood molecular etiology. Extensive studies at different molecular levels point to a high complexity of numerous interrelated pathways as the underpinnings of depression. Major
G. Fries +3 more
semanticscholar +1 more source
Bidirectional Association between Major Depressive Disorder and Gastroesophageal Reflux Disease:Mendelian Randomization Study [PDF]
, 2022 Background: Observational research has found a bidirectional relationship between major depressive disorder and gastroesophageal reflux disease; however, the causal association of this relationship is undetermined.
Chen, Jie +6 more
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