Results 21 to 30 of about 371,357 (236)

Neurobiology of Major Depressive Disorder [PDF]

Neural Plasticity, 2013
We survey studies which relate abnormal neurogenesis to major depressive disorder. Clinically, descriptive gene and protein expression analysis and genetic and functional studies revised here show that individual alterations of a complex signaling network, which includes the hypothalamic-pituitary-adrenal axis; the production of neurotrophins and ...
openaire   +3 more sources

Sensor-AssistedWeighted Average Ensemble Model for Detecting Major Depressive Disorder [PDF]

, 2019
The present methods of diagnosing depression are entirely dependent on self-report ratings or clinical interviews. Those traditional methods are subjective, where the individual may or may not be answering genuinely to questions.
Chang, Chuan-Yu, Gao, Liang, Garg, Akhil, Gutiérrez Reina, Daniel, Mahendran, Nivedhitha, Srinivasan, Kathiravan, Vincent, Durai Raj   +6 more
core   +1 more source

SUMOylation and Major Depressive Disorder

International Journal of Molecular Sciences, 2022
Since the discovery of the small ubiquitin-like modifier (SUMO) protein in 1995, SUMOylation has been considered a crucial post-translational modification in diverse cellular functions. In neurons, SUMOylation has various roles ranging from managing synaptic transmitter release to maintaining mitochondrial integrity and determining neuronal health.
Seok-Won Jeoung, Hyun-Sun Park, Zae Young Ryoo, Dong-Hyung Cho, Hyun-Shik Lee, Hong-Yeoul Ryu   +5 more
openaire   +2 more sources

A mega-Analysis of genome-wide association studies for major depressive disorder [PDF]

, 2013
Prior genome-wide association studies (GWAS) of major depressive disorder (MDD) have met with limited success. We sought to increase statistical power to detect disease loci by conducting a GWAS mega-analysis for MDD.
Lin, Danyu, Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium   +1 more
core   +2 more sources

Microstructural Correlates of Resilience against Major Depressive Disorder: Epigenetic Mechanisms? [PDF]

, 2010
Mental disorders are a major cause of long-term disability and are a direct cause of mortality, with approximately 800.000 individuals dying from suicide every year worldwide - a high proportion of them related to major depressive disorder (MDD)^1 ...
Andrew Fagan, Angela Carballedo, Danusia Lisiecka, Dermot Kelleher, Ian Daly, James Meaney, Thomas Frodl, Thomas Frodl, Yolande Ferguson   +8 more
core   +3 more sources

Trans-ancestry genome-wide study of depression identifies 697 associations implicating cell types and pharmacotherapies. [PDF]

In a genome-wide association study (GWAS) meta-analysis of 688,808 individuals with major depression (MD) and 4,364,225 controls from 29 countries across diverse and admixed ancestries, we identify 697 associations at 635 loci, 293 of which are novel ...
Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium. Electronic address: andrew.mcintosh@ed.ac.uk   +1 more
core   +1 more source

Comorbid depressive disorders in ADHD. the role of ADHD severity, subtypes and familial psychiatric disorders [PDF]

, 2014
ObjectiveaaTo evaluate the presence of Major Depressive Disorder (MDD) and Dysthymic Disorder (DD) in a sample of Italian children with Attention Deficit Hyperactivity Disorder (ADHD) and to explore specific features of comorbid depressive disorders in ...
Andriola E, Di Roma F, DI TRANI, MICHELA, Donfrancesco R., Leone D, Miano S, PARISI, Pasquale   +6 more
core   +1 more source

Epigenetic prediction of major depressive disorder [PDF]

Molecular Psychiatry, 2020
AbstractVariation in DNA methylation (DNAm) is associated with lifestyle factors such as smoking and body mass index (BMI) but there has been little research exploring its ability to identify individuals with major depressive disorder (MDD). Using penalised regression on genome-wide CpG methylation, we tested whether DNAm risk scores (MRS), trained on ...
Ian J. Deary, David J. Porteous, Heather C. Whalley, Toni-Kim Clarke, Xueyi Shen, Kathryn L. Evans, David M. Howard, David M. Howard, Andrew M. McIntosh, Stewart W. Morris, Yanni Zeng, Riccardo E. Marioni, Rosie M. Walker, Miruna C. Barbu   +13 more
openaire   +7 more sources

Tobacco smoking as a risk factor for major depressive disorder : a population-based study

, 2008
Background : Smoking is disproportionately prevalent among people with psychiatric illness. Aims : To investigate smoking as a risk factor for major depressive disorder. Method : A population-based sample of women was studied using case–control and
Berk, Michael, Henry, Margaret J., Jacka, Felice N., Kotowicz, Mark A., Ng, Felicity, Nicholson, Geoffrey C., Pasco, Julie A., Williams, Lana J.   +7 more
core   +1 more source

Severity of Depressive Symptoms and Accuracy of Dietary Reporting among Obese Women with Major Depressive Disorder Seeking Weight Loss Treatment [PDF]

, 2014
An elevation in symptoms of depression has previously been associated with greater accuracy of reported dietary intake, however this association has not been investigated among individuals with a diagnosis of major depressive disorder.
AJ Moshfegh, Andrew M. Busch, B Olendzki, Barbara C. Olendzki, Bradley M. Appelhans, CA Blanton, DA Cole, E Archer, FN Jacka, FS Luppino, Ira S. Ockene, J Tanakamatsumi, JA Linde, JA Tooze, Jerson Laks, Jessica L. Oleski, K Dobson, KD Strosahl, Kristin L. Schneider, L De Wit, LB Alloy, LE Burke, M Hamilton, M Yannakoulia, M Yannakoulia, MA Mendez, Matthew C. Whited, Michele A. DeBiasse, MJ Kretsch, Molly E. Waring, P Rohde, Philip A. Merriam, RC Kessler, RJ Hill, RR Briefel, S Pagoto, Sherry L. Pagoto, SJ Adams, Stephenie C. Lemon, Sybil L. Crawford, TN Akbaraly, Y Ma, Yunsheng Ma   +42 more
core   +3 more sources