Results 21 to 30 of about 786,893 (341)

Ketamine: A New Antidepressant? [PDF]

Psikiyatride Güncel Yaklaşımlar, 2015
Standart antidepressants are needed for the many individuals with major depressive disorder. However they do not respond adequately to treatment and because of a delay of weeks before the emergence of therapeutic effects.
Feride Karacaer
doaj   +1 more source

Cortical structural differences in major depressive disorder correlate with cell type-specific transcriptional signatures

Nature Communications, 2021
Major depressive disorder (MDD) has been shown to be associated with structural abnormalities in a variety of spatially diverse brain regions. However, the correlation between brain structural changes in MDD and gene expression is unclear.
Jiao Li, J. Seidlitz, J. Suckling, Feiyang Fan, Gong-Jun Ji, Yao Meng, Siqi Yang, Kai Wang, J. Qiu, Huafu Chen, W. Liao   +10 more
semanticscholar   +1 more source

Treating depressive disorders with the unified protocol: A preliminary randomized evaluation. [PDF]

, 2020
OBJECTIVES: This study aims to examine the efficacy of the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders (UP) for individuals diagnosed with a depressive disorder. METHOD: Participants included 44 adults who met criteria for major
Ametaj, Amantia A., Barlow, David H., Bentley, Kate H., Cardona, Nicole, Farchione, Todd J., Nauphal, Maya, Sauer-Zavala, Shannon, Steele, Stephanie Jarvi, Tirpak, Julianne Wilner, Wang, Mengxing   +9 more
core   +2 more sources

Psilocybin therapy increases cognitive and neural flexibility in patients with major depressive disorder

Translational Psychiatry, 2021
Psilocybin has shown promise for the treatment of mood disorders, which are often accompanied by cognitive dysfunction including cognitive rigidity.
Manoj K. Doss, M. Považan, M. Rosenberg, Nathan D. Sepeda, A. K. Davis, P. Finan, Gwenn S. Smith, J. Pekar, Peter B. Barker, R. Griffiths, F. Barrett   +10 more
semanticscholar   +1 more source

Real-world assessment of treatment inertia in the management of patients treated for major depressive disorder in the USA

Journal of Comparative Effectiveness Research, 2023
Aim: Major depressive disorder (MDD) is a debilitating illness in which depressive symptoms may persist after treatment. Treatment inertia is the continued use of the same pharmacotherapy regimen when treatment goals are not met.
John J Sheehan, Chris LaVallee, Keshia Maughn, Santosh Balakrishnan, Jacqueline A Pesa, Kruti Joshi, Craig Nelson   +6 more
doaj   +1 more source

Effects of Psilocybin-Assisted Therapy on Major Depressive Disorder

JAMA psychiatry, 2020
This randomized clinical trial examines the efficacy of psilocybin as an adjunct to psychotherapy and other treatments for major depressive disorder.
Alan K. Davis, F. Barrett, Darrick G. May, Mary P. Cosimano, Nathan D. Sepeda, Matthew W. Johnson, P. Finan, R. Griffiths   +7 more
semanticscholar   +1 more source

The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R).

Journal of the American Medical Association (JAMA), 2003
CONTEXT Uncertainties exist about prevalence and correlates of major depressive disorder (MDD). OBJECTIVE To present nationally representative data on prevalence and correlates of MDD by Diagnostic and Statistical Manual of Mental Disorders, Fourth ...
R. Kessler, P. Berglund, Olga V. Demler, R. Jin, D. Koretz, K. Merikangas, A. Rush, E. Walters, Philip S. Wang   +8 more
semanticscholar   +1 more source

Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors [PDF]

, 2022
BACKGROUND: Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden.
Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
core  

Major Depressive Disorder: Advances in Neuroscience Research and Translational Applications

Neuroscience Bulletin, 2021
Major depressive disorder (MDD), also referred to as depression, is one of the most common psychiatric disorders with a high economic burden. The etiology of depression is still not clear, but it is generally believed that MDD is a multifactorial disease
Zezhi Li, Meihua Ruan, Jun Chen, Yi-ru Fang   +3 more
semanticscholar   +1 more source

Major depressive disorder [PDF]

, 2007
Depression in its various forms is a commonly seen disorder in general practice. Indeed, over 90% of patients suffering from depression are seen, diagnosed and treated in primal) care.
Bonello, Arlene
core   +1 more source