Results 31 to 40 of about 496,245 (299)

SUMOylation and Major Depressive Disorder

International Journal of Molecular Sciences, 2022
Since the discovery of the small ubiquitin-like modifier (SUMO) protein in 1995, SUMOylation has been considered a crucial post-translational modification in diverse cellular functions. In neurons, SUMOylation has various roles ranging from managing synaptic transmitter release to maintaining mitochondrial integrity and determining neuronal health.
Seok-Won Jeoung, Hyun-Sun Park, Zae Young Ryoo, Dong-Hyung Cho, Hyun-Shik Lee, Hong-Yeoul Ryu   +5 more
openaire   +2 more sources

Non-REM sleep in major depressive disorder

NeuroImage: Clinical, 2022
Disturbed sleep is a key symptom in major depressive disorder (MDD). REM sleep alterations are well described in the current literature, but little is known about non-REM sleep alterations.
Leonore Bovy, Frederik D. Weber, Indira Tendolkar, Guillén Fernández, Michael Czisch, Axel Steiger, Marcel Zeising, Martin Dresler   +7 more
doaj   +1 more source

Immature defense mechanisms predict poor response to psychotherapy in major depressive patients with comorbid cluster B personality disorder

Brazilian Journal of Psychiatry, 2022
Objective: To evaluate the impact of defense mechanisms at baseline on depressive symptoms after brief psychotherapies and after 6-months of follow-up among depressed patients with and without cluster B personality disorders (PDs).
Carolina Rheingantz Scaini, Igor Soares Vieira, Rosiene Machado, Taiane de Azevedo Cardoso, Thaise Mondin, Luciano Souza, Mariane Lopez Molina, Karen Jansen, Ricardo Azevedo da Silva   +8 more
doaj   +1 more source

Tobacco smoking as a risk factor for major depressive disorder : a population-based study

, 2008
Background : Smoking is disproportionately prevalent among people with psychiatric illness. Aims : To investigate smoking as a risk factor for major depressive disorder. Method : A population-based sample of women was studied using case–control and
Berk, Michael, Henry, Margaret J., Jacka, Felice N., Kotowicz, Mark A., Ng, Felicity, Nicholson, Geoffrey C., Pasco, Julie A., Williams, Lana J.   +7 more
core   +1 more source

Hypermethylation in the ZBTB20 gene is associated with major depressive disorder [PDF]

, 2014
Background: Although genetic variation is believed to contribute to an individual's susceptibility to major depressive disorder, genome-wide association studies have not yet identified associations that could explain the full etiology of the disease ...
Alexis Battle, Anjali Henders, David A Collier, Emma Dempster, Enda Byrne, Fei Gao, Hanlin Lu, Honglong Wu, Jonathan Mill, Jordana T Bell, Jun Wang, Kirsten J Ward, Lutz Krause, Matthew N Davies, Naomi R Wray, Nicholas G Martin, null null, Pei-Chein Tsai, Sara Mostafavi, Therese Murphy, Tim D Spector, Xiaowei Zhu, Yuan Liu   +22 more
core   +2 more sources

Maintenance deep transcranial magnetic stimulation sessions are associated with reduced depressive relapses in patients with unipolar or bipolar depression [PDF]

, 2015
Introduction: Deep transcranial magnetic stimulation (dTMS) is a new form of TMS allowing safe stimulation of deep brain regions. The objective of this preliminary study was to assess the role of dTMS maintenance sessions in protecting patients with ...
ANGELETTI, Gloria, BERSANI, FRANCESCO SAVERIO, DEL CASALE, ANTONIO, DI PIETRO, SIMONE, Ferri, Vittoria R., GIRARDI, Paolo, Imperatori, Claudio, KOTZALIDIS, GEORGIOS, Raccah, Ruggero N., RAPINESI, CHIARA, SERATA, DANIELE, Zangen, Abraham   +11 more
core   +2 more sources

Retinoid homeostasis in major depressive disorder

Translational Psychiatry, 2023
The small, hormone-like molecule retinoic acid (RA) is a vital regulator in several neurobiological processes that are affected in depression. Next to its involvement in dopaminergic signal transduction, neuroinflammation, and neuroendocrine regulation ...
Lisa Rebecca Otto, Vera Clemens, Berk Üsekes, Nicoleta Carmen Cosma, Francesca Regen, Julian Hellmann-Regen   +5 more
doaj   +1 more source

Sleep‐disordered breathing in major depressive disorder [PDF]

, 2013
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/99077/1/jsr12029 ...
Armitage, Roseanne, Chen, Chiau‐fang, Cheng, Philip, D. Casement, Melynda, Deldin, Patricia J., Hoffmann, Robert F.   +5 more
core   +1 more source

Applying a Dynamical Systems Model and Network Theory to Major Depressive Disorder [PDF]

, 2019
Mental disorders like major depressive disorder can be seen as complex dynamical systems. In this study we investigate the dynamic behaviour of individuals to see whether or not we can expect a transition to another mood state.
Gordijn, Marijke C M, Kossakowski, Jolanda J, Riese, Harriette, Waldorp, Lourens J   +3 more
core   +3 more sources

Epigenetic prediction of major depressive disorder [PDF]

Molecular Psychiatry, 2020
AbstractVariation in DNA methylation (DNAm) is associated with lifestyle factors such as smoking and body mass index (BMI) but there has been little research exploring its ability to identify individuals with major depressive disorder (MDD). Using penalised regression on genome-wide CpG methylation, we tested whether DNAm risk scores (MRS), trained on ...
Ian J. Deary, David J. Porteous, Heather C. Whalley, Toni-Kim Clarke, Xueyi Shen, Kathryn L. Evans, David M. Howard, David M. Howard, Andrew M. McIntosh, Stewart W. Morris, Yanni Zeng, Riccardo E. Marioni, Rosie M. Walker, Miruna C. Barbu   +13 more
openaire   +7 more sources