BMEMat, EarlyView.A ROS‐responsive, zwitterionic nanocage enables stable, intranasal siRNA delivery to glioblastoma, promoting deep tumor penetration via non‐degradative pathways and trigeminal nerve transport. This platform achieves durable gene silencing and tumor suppression, offering a non‐invasive, storage‐stable strategy for treating glioma and other neurological ...
Jingwen Xie +12 more
wiley +1 more source
Retraction Note: Rapid and sustained antidepressant effects of intravenous ketamine in treatment-resistant major depressive disorder and suicidal ideation: a randomized clinical trial. [PDF]
BMC PsychiatryZolghadriha A +3 more
europepmc +1 more source
Brain Health, EarlyView.ABSTRACT Neurological disorders represent a critical domain within global health, necessitating advanced interventions to address complex pathologies such as tumors, functional disorders, and cerebrovascular diseases. Despite the proven benefits of early intervention, current treatment paradigms face significant challenges: (1) limited precision in ...
Qing Ye +14 more
wiley +1 more source
The ageing holobiont: crosstalk between telomere dynamics, oxidative stress and the gut microbiome
Biological Reviews, EarlyView.ABSTRACT The gut tissue is at the frontline of early onset of ageing. It exhibits high cell turnover rates and rapid telomere shortening, which can have systemic effects on the developing or senescing organism. We conducted a literature review of studies on the crosstalk between telomere length dynamics, telomerase activity, oxidative stress, and gut ...
Michael L. Pepke +2 more
wiley +1 more source
Intranasal 5-MeO-DMT Concomitant with SSRI for Treatment-Resistant Depression: A Proof-of-Concept Trial. [PDF]
CNS DrugsSeynaeve M +6 more
europepmc +1 more source
Catheterization and Cardiovascular Interventions, EarlyView.ABSTRACT Background Advanced heart failure (HF) remains a clinical challenge, and mitral transcatheter edge‐to‐edge repair (M‐TEER) has emerged as a potential bridging strategy. Aims To describe the clinical outcomes of M‐TEER in a single‐center cohort of patients with advanced HF and to identify anatomical and clinical features potentially associated ...
Pedro Castilhos de Freitas Crivelaro +8 more
wiley +1 more source
Racism at Work: A Critical Qualitative Investigation
The Career Development Quarterly, EarlyView.ABSTRACT An area of life that is profoundly impacted by anti‐Black racism is the world of work. Black Americans face persistent barriers from hiring to wage inequality to everyday mistreatment. In response, we conducted a critical qualitative investigation to explore how racism manifests in workplaces, uncover overlooked aspects of Black Americans ...
Michael Gordon +3 more
wiley +1 more source
Transcranial electric stimulation and neurocognitive training in clinically depressed patients: a pilot study of the effects on rumination [PDF]
, 2015 Bensenor, IM +6 more
core +2 more sources
Esketamine Nasal Spray: Mechanism of Action, Clinical, and Translational Science. [PDF]
Clin Transl Scivan Hoogdalem MW +3 more
europepmc +1 more source
Anti‐Obesity Pharmacotherapy and Emerging Multimodal Interventions for Obstructive Sleep Apnea
Chronic Diseases and Translational Medicine, EarlyView.Cellular and molecular mechanisms of obesity‐related obstructive sleep apnea (OSA). ADMA: asymmetric dimethyrarginine, NLRP3: nucleotide‐binding domain, leucine‐rich repeat family, Pyrin domain containing 3, TLR: toll‐like receptors, IL‐1β: interleukin‐1β, IL‐6: interleukin‐6; LPS: lipopolysacharide, ROS: reactive oxygen species, TNF‐α.
Anish Preshy +3 more
wiley +1 more source