Results 21 to 30 of about 83,135 (307)

Prognostic Significance of Blood-Based Baseline Biomarkers in Treatment-Resistant Depression: A Literature Review of Available Studies on Treatment Response

Brain Sciences, 2022
Major depressive disorder is a leading cause of disability worldwide and a major contributor to the overall global burden of disease. While there are several options for antidepressant treatment, only about 40–60% of patients respond to initial ...
Theano Gkesoglou, Stavroula I. Bargiota, Eleni Iordanidou, Miltiadis Vasiliadis, Vasilios-Panteleimon Bozikas, Agorastos Agorastos   +5 more
doaj   +1 more source

Electroconvulsive therapy mediates neuroplasticity of white matter microstructure in major depression. [PDF]

, 2014
Whether plasticity of white matter (WM) microstructure relates to therapeutic response in major depressive disorder (MDD) remains uncertain. We examined diffusion tensor imaging (DTI) correlates of WM structural connectivity in patients receiving ...
Clark, K, Espinoza, RT, Joshi, SH, Leaver, AM, Lyden, H, Narr, KL, Pirnia, T, Woods, RP   +7 more
core   +1 more source

Changes in sleep with transcranial magnetic stimulation in adults with treatment resistant depression: Preliminary results from a naturalistic study

European Psychiatry, 2021
Introduction Sleep disturbance specifically insomnia, non-restorative sleep, and hypersomnia are common symptoms of major depressive disorder (MDD).
A.I. Sonmez, R. Kay, S. Schmids, C. Peterson, A. Herman, A. Widge, Z. Nahas, C.S. Albott   +7 more
doaj   +1 more source

Dysfunctional Cortical Gradient Topography in Treatment-Resistant Major Depressive Disorder

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 2023
Treatment-resistant depression (TRD) refers to patients with major depressive disorder who do not remit after 2 or more antidepressant trials. TRD is common and highly debilitating, but its neurobiological basis remains poorly understood. Recent neuroimaging studies have revealed cortical connectivity gradients that dissociate primary sensorimotor ...
Lorenzo Pasquini, Susanna L. Fryer, Stuart J. Eisendrath, Zindel V. Segal, Alex J. Lee, Jesse A. Brown, Manish Saggar, Daniel H. Mathalon   +7 more
openaire   +4 more sources

Depression and sickness behavior are Janus-faced responses to shared inflammatory pathways [PDF]

, 2012
It is of considerable translational importance whether depression is a form or a consequence of sickness behavior. Sickness behavior is a behavioral complex induced by infections and immune trauma and mediated by pro-inflammatory cytokines.
A Bosutti, A Jellema, A Laugeray, A Peters, A Rossi-George, A Schaffner, AA Wadee, AH Swiergiel, AJ Grossberg, AL Hassett, AL Lacerda, AM Myint, AN van den Pol, AS El-Radhi, AS Wrynn, AY Lai, B Leonard, B Owe-Larsson, BE Leonard, BE Leonard, BG Charlton, BL Hart, Brian Leonard, C Celik, C Nathan, C Song, C Song, C Song, C Song, C Song, CA Stockmeier, Cai Song, CL Raison, D Brustolim, D Wang, DK Kinney, EA Stone, ES Wohleb, F Frenois, F Kapczinski, F Moroni, G Anderson, G Werner-Felmayer, George Anderson, GM MacQueen, GR Steinberg, H Anisman, H Anisman, H Nakanishi, HC Liu, HP Kopp, I Kirsch, IK Lampe, IR Bell, J Hannestad, J Steiner, JC O'Connor, JE Bower, JE Holmes, JL Rausch, JM Twenge, KJ Jung, KJ Tracey, KS Kendler, L MacDonald, L Qin, L Toker, LE Goehler, LE Goehler, Lisa Goehler, LJ Williams, LM Harden, LV Kessing, LV Kessing, M Adib-Conquy, M Berk, M Berk, M Berk, M Berk, M Catena-Dell'Osso, M Kauer-Sant'Anna, M Koenigs, M Kubera, M Kubera, M Lyte, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, MB Hennessy, MB Howren, MC McKinnon, MC Wichers, MC Wichers, MC Wichers, MD Burton, ME Sublette, Michael Berk, Michael Maes, MJ Hoes, MJ Kluger, MJ Kluger, MJ Sharman, MP Szuba, MT Berlim, N Castanon, N Castex, NA Harrison, O Caliyurt, O Takikawa, P Gorwood, P Taepavarapruk, P Videbech, Piotr Gałecki, R Dantzer, R Medzhitov, R Roubenoff, R Yirmiya, RC Bone, RH Straub, RJ Boland, RK Jewkes, RK Kumar, RM Post, RPA Gaykema, RPA Gaykema, RPA Gaykema, RW Johnson, S Bonaccorso, S Bonaccorso, S Cunningham-Rundles, S Lacosta, S Rantala, S-M Park, SC Strijdom, SD Burdette, SE Møller, SF Maier, SM Antelman, SM Jancsár, SM O'Brien, SM Sylvén, T Hochstrasser, T Liukkonen, T Sato, T Tuma, TA Lennie, TC Olde Hartman, TM Piser, V Gabbay, WC Drevets, WS Yang, Y Dowlati, Y Huang, Y Jiang, Y Kawasaki, Y Liu, Z Pavlovićc, Z Xia   +189 more
core   +2 more sources

Evaluating metabolites in patients with major depressive disorder who received mindfulness-based cognitive therapy and healthy controls using short echo MRSI at 7 Tesla. [PDF]

, 2016
ObjectivesOur aim was to evaluate differences in metabolite levels between unmedicated patients with major depressive disorder (MDD) and healthy controls, to assess changes in metabolites in patients after they completed an 8-week course of mindfulness ...
Eisendrath, Stuart, Gillung, Erin, Jakary, Angela, Li, Yan, Luks, Tracy, Mukherjee, Pratik, Nelson, Sarah J   +6 more
core   +3 more sources

A functional variant in the serotonin receptor 7 gene (HTR7), rs7905446, is associated with good response to SSRIs in bipolar and unipolar depression. [PDF]

, 2020
Predicting antidepressant response has been a clinical challenge for mood disorder. Although several genome-wide association studies have suggested a number of genetic variants to be associated with antidepressant response, the sample sizes are small and
Aitchison, Katherine J, Binder, Elisabeth B, Carrillo-Roa, Tania, Cattaneo, Annamaria, DeModena, Anna, Henigsberg, Neven, Kelsoe, John R, Leckband, Susan G, Liu, Jia Jia, McCarthy, Michael, Mors, Ole, Ren, Hongyan, Rietschel, Marcella, Shekhtman, Tatyana, Wei, Ya Bin   +14 more
core   +2 more sources

Treatment Resistant Depression and Sleep Apnea: A Case Report

Neuropsychiatric Investigation, 2015
Treatment resistance is an important issue in patients with depressive disorder and nearly a third of patients may not reach remission despite multiple drug trials.
Esra Aydın Sünbül, Hayal Ergin Toktaş, Hüseyin Güleç, Füsun Mayda Domaç, Ömer Yanartaş   +4 more
doaj   +1 more source

Clinical Guidelines of the Egyptian Psychiatric Association for the Management of Treatment-Resistant Unipolar Depression in Egypt

Frontiers in Psychiatry, 2022
BackgroundMajor depressive disorder (MDD) is a public health burden that creates a strain not only on individuals, but also on the economy. Treatment-resistant depression in the course of major depressive disorder represents a clinically challenging ...
Momtaz Abdel-Wahab, Tarek Okasha, Mostafa Shaheen, Mohamed Nasr, Tarek Molokheya, Abd ElNasser Omar, Menan A. Rabie, Victor Samy, Hany Hamed, Mohamed Ali   +9 more
doaj   +1 more source

Rare Copy Number Variation in Treatment-Resistant Major Depressive Disorder [PDF]

Biological Psychiatry, 2014
While antidepressant treatment response appears to be partially heritable, no consistent genetic associations have been identified. Large, rare copy number variants (CNVs) play a role in other neuropsychiatric diseases, so we assessed their association with treatment-resistant depression (TRD).We analyzed data from two genome-wide association studies ...
Colm, O'Dushlaine, Stephan, Ripke, Douglas M, Ruderfer, Steven P, Hamilton, Maurizio, Fava, Dan V, Iosifescu, Isaac S, Kohane, Susanne E, Churchill, Victor M, Castro, Caitlin C, Clements, Sarah R, Blumenthal, Shawn N, Murphy, Jordan W, Smoller, Roy H, Perlis   +13 more
openaire   +2 more sources