Results 41 to 50 of about 503,351 (293)

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

Pharmacological management of major depressive disorder

, 2022
Major depressive disorder [MDD] is a highly prevalent psychiatric disorder that causes significant impairment in different areas of one's life. There are multiple factors contributing to the development of MDD including genetic, environmental, and ...
Ojiako, Chiamaka Priscilla
core  

Multi-site benchmark classification of major depressive disorder using machine learning on cortical and subcortical measures [PDF]

Machine learning (ML) techniques have gained popularity in the neuroimaging field due to their potential for classifying neuropsychiatric disorders. However, the diagnostic predictive power of the existing algorithms has been limited by small sample ...
ENIGMA Major Depressive Disorder working group
core   +2 more sources

A systematic review and meta-analysis of psychological burden in family caregivers of patients with brain tumors

Scientific Reports
Family caregivers of brain tumor patients often experience severe psychological problems, with a high prevalence of mental health issues posing a growing challenge in clinical practice.
Haiyu Chen, Tianxiang Zou, Ziwei Teng, Yue Qin, Yizhi Deng, Renrong Wu, Jing Huang, Qiong Luo   +7 more
doaj   +1 more source

Depressive disorders.

American family physician, 2004
[no abstract available]
Geddes J. R., Butler R., Hatcher S., CIPRIANI, Andrea, BARBUI, Corrado, Price J., Carney S., Von Korff M.   +7 more
openaire   +7 more sources

Diffusion Spectrum Imaging Maps Early Axonal Loss and a Unique Progressive Signal in Neuronal Intranuclear Inclusion Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang, Yixiu Pei, Xiaobao Hu, Ying Xiong, Fang Wang, Yanyan Yu, Min Zhu, Dandan Tan, Meihong Zhou, Daojun Hong, Fuqing Zhou   +10 more
wiley   +1 more source

Anxiety and depression: One, two or three disorders? [PDF]

Psihologija, 2004
The study deals with theoretical psychiatric proposals about relations between anxiety and depressive disorders. Three theoretical positions developed on the basis of numerous evidence on relationship of anxiety and depressive disorders: unitaristic ...
Novović Zdenka
doaj   +1 more source

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

A retrospective analysis to estimate the healthcare resource utilization and cost associated with treatment-resistant depression in commercially insured US patients.

PLoS ONE, 2020
ObjectiveThe economic burden of commercially insured patients in the United States with treatment-resistant depression and patients with non-treatment-resistant major depressive disorder was compared using data from the Optum Clinformatics™ claims ...
Gang Li, Ling Zhang, Allitia DiBernardo, Grace Wang, John J Sheehan, Kwan Lee, Johan Reutfors, Qiaoyi Zhang   +7 more
doaj   +2 more sources

Glymphatic dysfunction associated with cortisol dysregulation in major depressive disorder

Translational Psychiatry
Cortisol dysregulation plays a critical role in the pathophysiology of depression, but its exact impact on the brain remains unclear. In this cross-sectional study, 210 participants, including 164 depressed patients and 46 healthy controls (HCs), were ...
Shengli Chen, Ziyun Xu, Zheng Guo, Shiwei Lin, Hongyuan Zhang, Qunjun Liang, Qianyun Chen, Yingli Zhang, Bo Peng, Yanzhen Zhao, Gangqiang Hou, Yingwei Qiu   +11 more
doaj   +1 more source