Results 61 to 70 of about 1,679,263 (303)

Glymphatic dysfunction associated with cortisol dysregulation in major depressive disorder

Translational Psychiatry
Cortisol dysregulation plays a critical role in the pathophysiology of depression, but its exact impact on the brain remains unclear. In this cross-sectional study, 210 participants, including 164 depressed patients and 46 healthy controls (HCs), were ...
Shengli Chen, Ziyun Xu, Zheng Guo, Shiwei Lin, Hongyuan Zhang, Qunjun Liang, Qianyun Chen, Yingli Zhang, Bo Peng, Yanzhen Zhao, Gangqiang Hou, Yingwei Qiu   +11 more
doaj   +1 more source

Using polygenic scores and clinical data for bipolar disorder patient stratification and lithium response prediction: machine learning approach

, 2022
Background Response to lithium in patients with bipolar disorder is associated with clinical and transdiagnostic genetic factors. The predictive combination of these variables might help clinicians better predict which patients will respond to lithium ...
Streit, Fabian, Ardau, Raffaella, the Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Akula, Nirmala, Cearns, Micah, Akiyama, Kazufumi, Frank, Joseph, Thalamuthu, Anbupalam, Adli, Mazda, Amare, Azmeraw T., Baune, Bernhard T., Schubert, Klaus Oliver   +11 more
core   +1 more source

Prodromal Lewy Body Disorder Features in REM Sleep Behavior Disorder With Biomarker‐Defined Synucleinopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid eye movement sleep behavior disorder (iRBD) is a prodromal state for Lewy body disorders and exhibits biological heterogeneity that may influence clinical expression and progression. We examined clinical features in individuals with iRBD and biomarker‐defined synucleinopathy.
Daniel Weintraub, Michele K. York, Roseanne Dobkin, Anuprita R. Nair, Ryan Kurth, David‐Erick Lafontant, Chelsea Caspell‐Garcia, Roy N. Alcalay, Ethan G. Brown, Lana M. Chahine, Christopher Coffey, Tatiana Foroud, Douglas Galasko, Karl Kieburtz, Kenneth Marek, Kalpana Merchant, Brit Mollenhauer, Kathleen L. Poston, Andrew Siderowf, Cristina Simonet, Tanya Simuni, Caroline M. Tanner, Thomas F. Tropea, Aleksandar Videnovic, The Parkinson's Progression Markers Initiative   +24 more
wiley   +1 more source

Multi-site benchmark classification of major depressive disorder using machine learning on cortical and subcortical measures [PDF]

Machine learning (ML) techniques have gained popularity in the neuroimaging field due to their potential for classifying neuropsychiatric disorders. However, the diagnostic predictive power of the existing algorithms has been limited by small sample ...
ENIGMA Major Depressive Disorder working group
core   +2 more sources

A retrospective analysis to estimate the healthcare resource utilization and cost associated with treatment-resistant depression in commercially insured US patients.

PLoS ONE, 2020
ObjectiveThe economic burden of commercially insured patients in the United States with treatment-resistant depression and patients with non-treatment-resistant major depressive disorder was compared using data from the Optum Clinformatics™ claims ...
Gang Li, Ling Zhang, Allitia DiBernardo, Grace Wang, John J Sheehan, Kwan Lee, Johan Reutfors, Qiaoyi Zhang   +7 more
doaj   +2 more sources

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

White Matter Microstructural Abnormalities in Neonatal Onset Genetic Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recent evidence indicates that epilepsy is associated with abnormal white matter. If seizures alter white matter, then the impact upon network function, epileptogenesis, and cognition could be pronounced in neonates undergoing rapid developmental myelination. Neonates with epilepsy due to nonstructural genetic causes provide a unique
Amanda G. Sandoval Karamian, Tianjia Zhu, Hao Huang, Shavonne L. Massey, Mark P. Fitzgerald, Darshana Parikh, Arastoo Vossough, Ingo Helbig, Nicholas S. Abend   +8 more
wiley   +1 more source

The Role of MAPK in Depressive Disorder and Research on Related Drugs

Shengwu huaxue yu shengwu wuli jinzhan
Depressive disorder is a prevalent mental illness characterized by pronounced and enduring symptoms of depression and cognitive impairment. The escalating pressures of modern society have led to a corresponding rise in the number of depressive disorder ...
WANG Chun-Yu, LIU Yan-Xia
doaj   +1 more source

Association between allergic diseases, generalized anxiety disorder, and depressive symptoms in South Korean adolescents: a secondary data analysis of the 2022 Korea Youth Risk Behavior Survey [PDF]

Child Health Nursing Research
Purpose This study investigated the relationship between allergic diseases, general anxiety disorder, and depressive symptoms among Korean adolescents.
Jaeyoung Lee, So Yeon Park
doaj   +1 more source

Depression and its association with psychological factors among adolescents living with HIV in Southwestern Nigeria

BMC Psychiatry, 2023
Objective The aim was to determine the prevalence of depressive disorder and associated psychological factors among adolescents living with HIV/AIDS. Methods One hundred and five adolescents with HIV were assessed for self-esteem, internalized HIV stigma
Lawal RO, Adesanmi Akinsulore, Oginni OA, Aloba OO, Mosaku SK, Akanmu AS   +5 more
doaj   +1 more source