Results 71 to 80 of about 3,696,874 (383)

Timing and Predictive Value of Clinical Conditions Preceding Multiple Sclerosis in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Multiple sclerosis (MS) patients often experience a higher incidence of clinical conditions before diagnosis, suggesting a prodromal phase. However, their predictive value and temporal trajectories remain underexplored. We investigated these aspects using the large UK Biobank's population‐based cohort, which provided clinical ...
Andrea Nova, Teresa Fazia, Giovanni Di Caprio, Davide Gentilini, Luisa Bernardinelli, Roberto Bergamaschi   +5 more
wiley   +1 more source

Understanding the role of P2X7 in affective disorders—are glial cells the major players? [PDF]

, 2015
Pathophysiology associated with several psychiatric disorders has been linked to inflammatory biomarkers. This has generated a theory of major depressive disorders as an inflammatory disease.
Jenkins, Trisha A., Spencer, Sarah J., Stokes, Leanne   +2 more
core   +2 more sources

Recognition and Treatment of Cognitive Dysfunction in Major Depressive Disorder

Frontiers in Psychiatry, 2018
Major Depressive Disorder (MDD) is a prevalent, chronic, disabling, and multidimensional mental disorder. Cognitive dysfunction represents a core diagnostic and symptomatic criterion of MDD, and is a principal determinant of functional non-recovery ...
Hannah Zuckerman, Z. Pan, Caroline Park, E. Brietzke, Natalie Musial, Aisha S. Shariq, M. Iacobucci, Samantha J. Yim, L. Lui, Carola Rong, R. McIntyre   +10 more
semanticscholar   +1 more source

Depression: The Disorder and the Burden

Indian Journal of Psychological Medicine, 2010
Byline: M. Reddy Depression, the common psychological disorder, affects about 121 million people worldwide. World Health Organization (WHO) states that depression is the leading cause of disability as measured by Years Lived with Disability (YLDs) and the fourth leading contributor to the global burden of disease.
openaire   +4 more sources

Clinical Characteristics of Parkinsonism in HTLV‐1‐Associated Myelopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Human T‐lymphotropic virus type 1 (HTLV‐1)‐associated myelopathy/tropical spastic paraparesis (HAM/TSP) is the classic neurological manifestation of HTLV‐1 infection; however, this virus has also been associated with other neurological disorders. Concurrent parkinsonism is relatively rare and presents diagnostic challenges.
Mika Dozono, Satoshi Nozuma, Shota Hirakata, Takashi Yoshida, Daisuke Kodama, Masakazu Tanaka, Eiji Matsuura, Ryuji Kubota, Hiroshi Takashima   +8 more
wiley   +1 more source

Structural and functional abnormities of amygdala and prefrontal cortex in major depressive disorder with suicide attempts [PDF]

, 2013
Finding neural features of suicide attempts (SA) in major depressive disorder (MDD) may be helpful in preventing suicidal behavior. The ventral and medial prefrontal cortex (PFC), as well as the amygdala form a circuit implicated in emotion regulation ...
Wang, Lifei, Zhao, Yimeng, Edmiston, Elliot K, Womer, Fay Y, Zhang, Ran, Zhao, Pengfei, Jiang, Xiaowei, Wu, Feng, Kong, Lingtao, Zhou, Yifang, Tang, Yanqing, Wei, Shengnan   +11 more
core   +5 more sources

Early clinical predictors and correlates of long-term morbidity in bipolar disorder [PDF]

, 2017
OBJECTIVES: Identifying factors predictive of long-term morbidity should improve clinical planning limiting disability and mortality associated with bipolar disorder (BD).
Baldessarini, R. J., DE CHIARA, Lavinia, Girardi, Paolo, Koukopoulos, A. E., Koukopoulos, Alexia, Reginaldi, D., Sani, Gabriele, Serra, Giulia, Tondo, L.   +8 more
core   +1 more source

Epigenetic Aging in Major Depressive Disorder.

American Journal of Psychiatry, 2018
OBJECTIVE Major depressive disorder is associated with an increased risk of mortality and aging-related diseases. The authors examined whether major depression is associated with higher epigenetic aging in blood as measured by DNA methylation (DNAm ...
Laura K. M. Han, M. Aghajani, S. Clark, R. Chan, M. Hattab, A. Shabalin, Min Zhao, G. Kumar, Lin Y. Xie, R. Jansen, Y. Milaneschi, B. Dean, K. Åberg, E. J. van den Oord, B. Penninx   +14 more
semanticscholar   +1 more source

Symptoms of Depression But Not Depressive Disorder

Journal of the American College of Cardiology, 2011
I thank Hoen et al. ([1][1]) and the Heart and Soul Study for drawing attention to the psychological factors that co-occur with and influence cardiovascular (CV) disease. Hoen et al. ([1][1]) reported exciting results with individual symptoms predicting CV events.
openaire   +2 more sources

Identification of Dementia With Lewy Bodies by Skin Biopsy in Recent‐Onset Cognitive Impairment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Immunofluorescence for phosphorylated alpha‐synuclein in skin biopsy samples is an emerging biomarker in synucleinopathies comprising Dementia with Lewy bodies. In this pilot study, 19 patients with recent‐onset (≤ 18 months) cognitive impairment underwent skin biopsy at baseline, with follow‐up clinical re‐evaluation.
Alessandro Furia, Alex Incensi, Cecilia Delprete, Giovanni Rizzo, Salvatore Bonvegna, Marco Piatti, Enrica Olivola, Francesco Ventruto, Veria Vacchiano, Enrico Fileccia, Roberto Cilia, Nicola Modugno, Rocco Liguori, Vincenzo Donadio   +13 more
wiley   +1 more source