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Drug target mining and in silico screening of Tibetan plant metabolites for potential alleviation of Oroya fever, a neglected tropical disease. [PDF]

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Basharat Z   +9 more
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Depsidone synthesis. Part 19. Some β-orcinol depsidones

J. Chem. Soc., Perkin Trans. 1, 1981
The synthesis of the lichen depsidones 3,8-dihydroxy-1,4,6,9-tetramethyl-11-oxo-11H-dibenzo[b,e][1,4]-dioxepin-7-carboxylic acid (hypoprotocetraric acid)(4), 8-hydroxy-3-methoxy-1,4,6,9-tetramethyl-11-oxo-11H-dibenzo[b,e][1,4]dioxepin-7-carboxylic acid (O-methylhyprprotocetraric acid)(5), 4-formyl-3,8-dihydroxy-1,6,9-trimethyl-11-oxo-11H-dibenzo[b,e][1,
Tony Sala, Melvyn V. Sargent
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Depsidone synthesis. Part 11. Synthesis of some fungal depsidones related to nidulin

Journal of the Chemical Society, Perkin Transactions 1, 1978
The synthesis of 3-hydroxy-8-methoxy-1,9-dimethyl-6-(s-butyl)dibenzo[b,e][1,4]dioxepin-11-one (tridechlorodihydronidulin)(34), a derivative of the fungal depsidone nidulin (1), and of 3,8-dihydroxy-1,9-dimethyl-6-(s-butyl)dibenzo[b,e][1,4]dioxepin-11-one (tridechlorodihydro-O-nornidulin)(39), a derivative of the fungal depsidone tridechloro-O ...
Peter Djura, Melvyn V. Sargent
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Depsidone synthesis. XII. Some exploratory synthetic routes to highly functionalized depsidones

Australian Journal of Chemistry, 1978
Attempts to synthesize the depsidones virensic acid (1), physciosporin (2), and pannarin (3) by routes based on the Ullmann ether condensation and the Hems reaction are described. Selective functionalization of highly substituted p-xylenes by photobromination is reported.
T Sala, MV Sargent
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Antioxidant activity of depsides and depsidones

Phytochemistry, 1994
The antioxidant activity of lichenic metabolites, depsides and depsidones, was assessed by their effects as inhibitors of rat brain homogenate auto-oxidation and beta-carotene oxidation. The results obtained in both systems indicate that lichenic metabolites afford a moderate protection in the microM concentration range. The largest effect was measured
M E, Hidalgo   +3 more
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Structure of the lichen depsidone pannarin

Journal of the Chemical Society, Chemical Communications, 1974
The published structure of pannarin{2-chloro-6-hydroxy-3-methoxy-1,4,8-trimethyl-11-oxo-11H-dibenzo[b,e]-[1,4]dioxepin-7-carbaldehyde}(1) is revised to 2-chloro-3-hydroxy-8-methoxy-1,6,9-trimethyl-11-oxo-11H-dibenzo[b,e][1,4]dioxepin-4-carbaldehyde (21), in the light of a combination of degradative, spectroscopic, and synthetic studies.
David A. Jackman   +2 more
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