Results 1 to 10 of about 1,230 (129)

Recent advances on natural depsidones: sources, biosynthesis, structure-activity relationship, and bioactivities [PDF]

PeerJ, 2023
Depsidones are a class of polyphenolic polyketides that have been proposed to be biosynthesized from oxidative coupling of esters of two polyketidic benzoic acid derivatives. They are principally encountered in fungi and lichens.
Maan T. Khayat, Kholoud F. Ghazawi, Waad A. Samman, Aisha A. Alhaddad, Gamal A. Mohamed, Sabrin RM Ibrahim   +5 more
doaj   +4 more sources

From Mushrooms to Molecules: Exploring Depsidones in Ganoderma lucidum for Antioxidant and Anticancer Applications [PDF]

Molecules
Fungi are a prolific source of diverse bioactive metabolites, yet many remain unexplored. Among these, depsidones are a rare class of compounds with significant biological potential, but they are seldom reported in mushrooms.
Sayed H. A. Mohamed, Yehia A.-G. Mahmoud, Mohamed Y. Bediway, Sobhy E. Elsilk, Mohammed Yosri, Kamel Metwally, Nader E. Abo-Dya, Galal Yahya, Mervt Almostafa, Atef A. El-Hela   +9 more
doaj   +3 more sources

Structure-Based Virtual Screening and Molecular Dynamics Simulation Assessments of Depsidones as Possible Selective Cannabinoid Receptor Type 2 Agonists [PDF]

Molecules, 2023
The discovery of natural drug metabolites is a leading contributor to fulfilling the sustainable development goal of finding solutions to global health challenges.
Gamal A. Mohamed, Abdelsattar M. Omar, Dana F. AlKharboush, Mona A. Fallatah, Ikhlas A. Sindi, Dina S. El-Agamy, Sabrin R. M. Ibrahim   +6 more
doaj   +3 more sources

Brominated Depsidones with Antibacterial Effects from a Deep-Sea-Derived Fungus Spiromastix sp. [PDF]

Marine Drugs
Eleven new brominated depsidones, namely spiromastixones U-Z5 (1–11) along with five known analogues (12–16), were isolated from a deep-sea-derived fungus Spiromastix sp. through the addition of sodium bromide during fermentation.
Zequan Huang, Dong Liu, Shang Chen, Jinwei Ren, Chenghai Gao, Zhiyong Li, Aili Fan, Wenhan Lin   +7 more
doaj   +3 more sources

Unveiling the therapeutic potential of Lobaria extract and its depsides/depsidones in combatting Aβ42 peptides aggregation and neurotoxicity in Alzheimer’s disease [PDF]

Frontiers in Pharmacology
Background: The development of effective inhibitors that can inhibit amyloid β (Aβ) peptides aggregation and promote neurite outgrowth is crucial for the possible treatment of Alzheimer’s disease (AD).
Meixia Yang, Meixia Yang, Caishan Yan, Dusadee Ospondpant, Dusadee Ospondpant, Lisong Wang, Shengying Lin, Shengying Lin, Wai Lun Tang, Wai Lun Tang, Tina Tingxia Dong, Tina Tingxia Dong, Penger Tong, Qin Xu, Karl Wah Keung Tsim, Karl Wah Keung Tsim   +15 more
doaj   +3 more sources

Evaluation of anti-tumour properties of two depsidones – Unguinol and Aspergillusidone D – in triple-negative MDA-MB-231 breast tumour cells

Toxicology Reports, 2019
There is an ongoing search for new compounds to lower the mortality and recurrence of breast cancer, especially triple-negative breast cancer. Naturally occurring depsidones, extracted from the fungus Aspergillus, are known for their wide range of ...
Majorie Van Duursen, Prasat Kittakoop
exaly   +4 more sources

Depsidones inhibit aromatase activity and tumor cell proliferation in a co-culture of human primary breast adipose fibroblasts and T47D breast tumor cells

Toxicology Reports, 2017
Naturally occurring depsidones from the marine fungus Aspergillus unguis are known to have substantial anti-cancer activity, but their mechanism of action remains elusive. The purpose of this study was to examine the anti-aromatase activity of two common
Anne Zwartsen, Martin Van Den Berg, Suthat Chottanapund   +2 more
exaly   +4 more sources

The depsidones from marine sponge-derived fungus Aspergillus unguis IB151 as an anti-MRSA agent: Molecular docking, pharmacokinetics analysis, and molecular dynamic simulation studies. [PDF]

Saudi Pharm J, 2023
Methicillin-resistant Staphylococcus aureus (MRSA) is an emerging nosocomial pathogen among hospitalized patients, with high morbidity and mortality rates. The discovery of a novel antibacterial is urgently needed to address this resistance problem.
Handayani D, Aminah I, Pontana Putra P, Eka Putra A, Arbain D, Satriawan H, Efdi M, Celik I, Ekawati Tallei T.   +8 more
europepmc   +2 more sources

Characterization of the depsidone gene cluster reveals etherification, decarboxylation and multiple halogenations as tailoring steps in depsidone assembly [PDF]

Acta Pharmaceutica Sinica B, 2023
Depsides and depsidones have attracted attention for biosynthetic studies due to their broad biological activities and structural diversity. Previous structure‒activity relationships indicated that triple halogenated depsidones display the best anti ...
Jiafan Yang, Zhenbin Zhou, Yingying Chen, Yongxiang Song, Jianhua Ju   +4 more
doaj   +2 more sources

Fungal Depsidones Stimulate AKT-Dependent Glucose Uptake in 3T3-L1 Adipocytes. [PDF]

J Nat Prod
Enhanced glucose uptake in insulin-sensitive tissues is one of the therapeutic strategies to ameliorate hyperglycemia and maintain glucose homeostasis in type 2 diabetes.
Chantarasakha K, Yangchum A, Isaka M, Tepaamorndech S.   +3 more
europepmc   +2 more sources