Characterization of the depsidone gene cluster reveals etherification, decarboxylation and multiple halogenations as tailoring steps in depsidone assembly [PDF]
Acta Pharmaceutica Sinica B, 2023 Depsides and depsidones have attracted attention for biosynthetic studies due to their broad biological activities and structural diversity. Previous structure‒activity relationships indicated that triple halogenated depsidones display the best anti ...
Jiafan Yang +4 more
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Recent advances on natural depsidones: sources, biosynthesis, structure-activity relationship, and bioactivities [PDF]
PeerJ, 2023 Depsidones are a class of polyphenolic polyketides that have been proposed to be biosynthesized from oxidative coupling of esters of two polyketidic benzoic acid derivatives. They are principally encountered in fungi and lichens.
Maan T. Khayat +5 more
doaj +3 more sources
Secondary Metabolites Diversity of Aspergillus unguis and Their Bioactivities: A Potential Target to Be Explored [PDF]
Biomolecules, 2022 Aspergillus unguis belongs to the Aspergillus section Nidulantes. This species is found in soils and organisms from marine environments, such as jellyfishes and sponges. The first chemical study reported in the literature dates from 1970, with depsidones
Levy Tenório Sousa Domingos +5 more
doaj +2 more sources
In Vitro and In Vivo Anti-Phytopathogenic Fungal Activity of a Culture Extract of the Marine-Derived Fungus, Aspergillus unguis KUFA 0098, and Its Major Depsidone Constituents [PDF]
Marine DrugsThe crude ethyl acetate extract of the culture of a marine sponge-associated fungus, Aspergillus unguis KUFA 0098, was tested for its capacity to inhibit the growth of ten phytopathogenic fungi, viz.
Decha Kumla +7 more
doaj +2 more sources
Structure-Based Virtual Screening and Molecular Dynamics Simulation Assessments of Depsidones as Possible Selective Cannabinoid Receptor Type 2 Agonists [PDF]
Molecules, 2023 The discovery of natural drug metabolites is a leading contributor to fulfilling the sustainable development goal of finding solutions to global health challenges.
Gamal A. Mohamed +6 more
doaj +2 more sources
From Mushrooms to Molecules: Exploring Depsidones in Ganoderma lucidum for Antioxidant and Anticancer Applications [PDF]
MoleculesFungi are a prolific source of diverse bioactive metabolites, yet many remain unexplored. Among these, depsidones are a rare class of compounds with significant biological potential, but they are seldom reported in mushrooms.
Sayed H. A. Mohamed +9 more
doaj +2 more sources
Lichen-Derived Diffractaic Acid Inhibited Dengue Virus Replication in a Cell-Based System [PDF]
Molecules, 2023 Dengue is a mosquito-borne flavivirus that causes 21,000 deaths annually. Depsides and depsidones of lichens have previously been reported to be antimicrobials. In this study, our objective was to identify lichen-derived depsides and depsidones as dengue
Naphat Loeanurit +10 more
doaj +2 more sources
Toxicology Reports, 2017 Naturally occurring depsidones from the marine fungus Aspergillus unguis are known to have substantial anti-cancer activity, but their mechanism of action remains elusive. The purpose of this study was to examine the anti-aromatase activity of two common
Suthat Chottanapund +2 more
exaly +3 more sources
Theoretical Study on the Antioxidant Activity of Natural Depsidones [PDF]
ACS Omega, 2020 Depsidones are secondary metabolites in lichens with a range of potential health benefits. Among others, these compounds are believed to exhibit high hydroxyl radical and superoxide scavenging abilities, warranting a detailed investigation of their antioxidant properties.
Mai Van Bay +6 more
doaj +3 more sources
Toxicology Reports, 2019 There is an ongoing search for new compounds to lower the mortality and recurrence of breast cancer, especially triple-negative breast cancer. Naturally occurring depsidones, extracted from the fungus Aspergillus, are known for their wide range of ...
Prasat Kittakoop +2 more
exaly +3 more sources