Results 1 to 10 of about 831 (142)

From Mushrooms to Molecules: Exploring Depsidones in Ganoderma lucidum for Antioxidant and Anticancer Applications [PDF]

Molecules
Fungi are a prolific source of diverse bioactive metabolites, yet many remain unexplored. Among these, depsidones are a rare class of compounds with significant biological potential, but they are seldom reported in mushrooms.
Sayed H. A. Mohamed, Yehia A.-G. Mahmoud, Mohamed Y. Bediway, Sobhy E. Elsilk, Mohammed Yosri, Kamel Metwally, Nader E. Abo-Dya, Galal Yahya, Mervt Almostafa, Atef A. El-Hela   +9 more
doaj   +3 more sources

Recent advances on natural depsidones: sources, biosynthesis, structure-activity relationship, and bioactivities [PDF]

PeerJ, 2023
Depsidones are a class of polyphenolic polyketides that have been proposed to be biosynthesized from oxidative coupling of esters of two polyketidic benzoic acid derivatives. They are principally encountered in fungi and lichens.
Maan T. Khayat, Kholoud F. Ghazawi, Waad A. Samman, Aisha A. Alhaddad, Gamal A. Mohamed, Sabrin RM Ibrahim   +5 more
doaj   +5 more sources

Depsidones inhibit aromatase activity and tumor cell proliferation in a co-culture of human primary breast adipose fibroblasts and T47D breast tumor cells [PDF]

Toxicology Reports, 2017
Naturally occurring depsidones from the marine fungus Aspergillus unguis are known to have substantial anti-cancer activity, but their mechanism of action remains elusive. The purpose of this study was to examine the anti-aromatase activity of two common
Anne Zwartsen, Martin van den Berg, Suthat Chottanapund   +2 more
exaly   +4 more sources

Biosynthetic gene cluster synteny: Orthologous polyketide synthases in Hypogymnia physodes, Hypogymnia tubulosa, and Parmelia sulcata [PDF]

MicrobiologyOpen, 2023
Lichens are symbiotic associations consisting of a photobiont (algae or cyanobacteria) and a mycobiont (fungus), which together generate a variety of unique secondary metabolites.
Nadim Ahmad, Manfred Ritz, Anjuli Calchera, Jürgen Otte, Imke Schmitt, Thomas Brueck, Norbert Mehlmer   +6 more
doaj   +3 more sources

Characterization of the depsidone gene cluster reveals etherification, decarboxylation and multiple halogenations as tailoring steps in depsidone assembly [PDF]

Acta Pharmaceutica Sinica B, 2023
Depsides and depsidones have attracted attention for biosynthetic studies due to their broad biological activities and structural diversity. Previous structure‒activity relationships indicated that triple halogenated depsidones display the best anti ...
Jiafan Yang, Zhenbin Zhou, Yingying Chen, Yongxiang Song, Jianhua Ju   +4 more
doaj   +2 more sources

Chemo-Diversity and Secondary Metabolite Content in Corticolous Crustose Lichens (Fam. Arthoniaceae, Graphidaceae, Pyrenulaceae) from Remnants of Colombian Tropical Dry Forests [PDF]

Journal of Fungi
Colombia ranks third among South American countries in terms of fungal diversity (including lichens); however, the lichen diversity of tropical dry forest ecosystems, particularly those in the Caribbean region, remains relatively understudied.
Pierine España-Puccini, Amner Muñoz-Acevedo, Natalia A. Llanos-López, Marc Stadler, Mayar L. Ganoza-Yupanqui, Paula S. Burgos-Zelada, María C. Martínez-Habibe   +6 more
doaj   +2 more sources

Deciphering the biosynthetic pathways of lichen acids. [PDF]

New Phytol
Summary Depsides and depsidones are polyketide‐derived lichen acids widely distributed in lichen thalli, yet the biosynthetic gene clusters (BGCs) responsible for their production remain poorly understood. To address this gap, we investigated the diversity and evolutionary relationships of polyketide BGCs in lichens.
Kim W, Shishido TK, Pham HT, Kang KB, Liu R, Wahlsten M, Collemare J, Park H, Oh SO, Ha HH, Kim H, Hur JS.   +11 more
europepmc   +2 more sources

In Vitro and In Vivo Anti-Phytopathogenic Fungal Activity of a Culture Extract of the Marine-Derived Fungus, Aspergillus unguis KUFA 0098, and Its Major Depsidone Constituents [PDF]

Marine Drugs
The crude ethyl acetate extract of the culture of a marine sponge-associated fungus, Aspergillus unguis KUFA 0098, was tested for its capacity to inhibit the growth of ten phytopathogenic fungi, viz.
Decha Kumla, Diana I. C. Pinho, Emília Sousa, Tida Dethoup, Luis Gales, Sharad Mistry, Artur M. S. Silva, Anake Kijjoa   +7 more
doaj   +2 more sources

Secondary Metabolites Diversity of Aspergillus unguis and Their Bioactivities: A Potential Target to Be Explored [PDF]

Biomolecules, 2022
Aspergillus unguis belongs to the Aspergillus section Nidulantes. This species is found in soils and organisms from marine environments, such as jellyfishes and sponges. The first chemical study reported in the literature dates from 1970, with depsidones
Levy Tenório Sousa Domingos, Raquel dos Santos Martins, Leonardo Melo de Lima, Angela Michelato Ghizelini, Antonio Ferreira-Pereira, Fernando Cotinguiba   +5 more
doaj   +2 more sources

Lichen-Derived Diffractaic Acid Inhibited Dengue Virus Replication in a Cell-Based System [PDF]

Molecules, 2023
Dengue is a mosquito-borne flavivirus that causes 21,000 deaths annually. Depsides and depsidones of lichens have previously been reported to be antimicrobials. In this study, our objective was to identify lichen-derived depsides and depsidones as dengue
Naphat Loeanurit, Truong Lam Tuong, Van-Kieu Nguyen, Vipanee Vibulakhaophan, Kowit Hengphasatporn, Yasuteru Shigeta, Si Xian Ho, Justin Jang Hann Chu, Thanyada Rungrotmongkol, Warinthorn Chavasiri, Siwaporn Boonyasuppayakorn   +10 more
doaj   +2 more sources