Evaluation of anti-tumour properties of two depsidones – Unguinol and Aspergillusidone D – in triple-negative MDA-MB-231 breast tumour cells [PDF]
Toxicology Reports, 2019 There is an ongoing search for new compounds to lower the mortality and recurrence of breast cancer, especially triple-negative breast cancer. Naturally occurring depsidones, extracted from the fungus Aspergillus, are known for their wide range of ...
Majorie B.M. van Duursen +1 more
exaly +5 more sources
Lichen-Derived Bioactive Compounds in Diabetes and Cardiovascular Risk: Experimental Evidence, Mechanisms, and Translational Challenges [PDF]
BiomedicinesCardiometabolic disorders arise from interconnected metabolic, inflammatory, oxidative, mitochondrial, and vascular abnormalities. Lichens produce structurally diverse secondary metabolites, including depsides, depsidones, dibenzofurans, anthraquinones ...
Alfredo Torres-Benítez +9 more
doaj +2 more sources
Penicillides from Penicillium and Talaromyces: Chemical Structures, Occurrence and Bioactivities [PDF]
MoleculesPenicillide is the founder product of a class of natural products of fungal origin. Although this compound and its analogues have been identified from taxonomically heterogeneous fungi, they are most frequently and typically reported from the species of ...
Maria Michela Salvatore +3 more
doaj +2 more sources
Brominated Depsidones with Antibacterial Effects from a Deep-Sea-Derived Fungus Spiromastix sp. [PDF]
Marine DrugsEleven new brominated depsidones, namely spiromastixones U-Z5 (1–11) along with five known analogues (12–16), were isolated from a deep-sea-derived fungus Spiromastix sp. through the addition of sodium bromide during fermentation.
Zequan Huang +7 more
doaj +2 more sources
Extraction of lichen bioactive compounds using volatile natural deep eutectic solvents and comparative analytical approaches [PDF]
Scientific ReportsLichens are a source of bioactive secondary metabolites with different pharmacological activities. However, these metabolites are challenging regarding their extraction.
S. Dresler +9 more
doaj +2 more sources
Unveiling the therapeutic potential of Lobaria extract and its depsides/depsidones in combatting Aβ42 peptides aggregation and neurotoxicity in Alzheimer’s disease [PDF]
Frontiers in PharmacologyBackground: The development of effective inhibitors that can inhibit amyloid β (Aβ) peptides aggregation and promote neurite outgrowth is crucial for the possible treatment of Alzheimer’s disease (AD).
Meixia Yang +15 more
doaj +2 more sources
Natural Product Communications, 2012 Two depsides and five depsidones, isolated from lichens, were tested to determine their in vivo protective effects on tobacco leaves challenged with Tobacco Mosaic Virus (TMV).
Luis Espinoza +2 more
exaly +2 more sources
Theoretical Study on the Antioxidant Activity of Natural Depsidones
ACS Omega, 2020 Depsidones are secondary metabolites in lichens with a range of potential health benefits. Among others, these compounds are believed to exhibit high hydroxyl radical and superoxide scavenging abilities, warranting a detailed investigation of their ...
Mai Van Bay +6 more
doaj +2 more sources
Separations, 2022 Lichens are symbiotic organisms between algae and fungi, which are makers of secondary compounds named as lichen substances. Hyphenated techniques have significantly helped natural product chemistry, especially UHPLC/ESI/MS/MS in the identification ...
Beatriz Sepúlveda +4 more
doaj +1 more source
Molecules, 2023 The discovery of natural drug metabolites is a leading contributor to fulfilling the sustainable development goal of finding solutions to global health challenges.
Gamal A. Mohamed +6 more
doaj +1 more source