Results 41 to 50 of about 474,599 (267)
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
AnimalsMonitoring calf body weight (BW) before weaning is essential for assessing growth, feed efficiency, health, and weaning readiness. However, labor, time, and facility constraints limit BW collection.
Mingsi Liao +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Texture Synthesis Repair of RealSense D435i Depth Images with Object-Oriented RGB Image Segmentation
Sensors, 2020 A depth camera is a kind of sensor that can directly collect distance information between an object and the camera. The RealSense D435i is a low-cost depth camera that is currently in widespread use.
Longyu Zhang, Hao Xia, Yanyou Qiao
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Human Recognition Based on the Depth Image in Rail Vehicle
机车电传动, 2014 A method based on depth image local normal vector characteristic, described by spherical coordinate parameters ( , ), was proposed in this paper and suited to rail vehicle with the high-density passengers. This method implemented the human recognition by
TONG Lu +3 more
doaj
HUMAN POSE RECOGNITION USING GEODESIC DISTANCE AND COLOR FEATURES WITH DEPTH CAMERA
Tạp chí Khoa học Đại học Đà Lạt, 2017 The paper presents an approach to recover a full-body 3D human pose using geodesic and color features captured by a depth camera. The 3D information obtained from the depth images is employed to represent the points belonging to a human body in the form ...
Đinh Đồng Lưỡng
doaj +1 more source