Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Lehren mit KI: Learning Analytics für mehr Studierendenorientierung in der Hochschullehre?
A Digital Education: AI A.1:1 Learning Analytics in der Hochschullehre 2 Das Projekt ‚Learning Analytics – Studierende im Fokus‘ 3 Herausforderungen und Chancen der Integration von Learning Analytics in die Lehre 4 Zusammenfassung und AusblickBereits ...
Egger, Rudolf +2 more
core
Migrants’ rights and immigrant integration in German political party discourse
, 2010 Gerdes J. Migrants’ rights and immigrant integration in German political party discourse. COMCAD Arbeitspapiere - working papers. Vol 90. Bielefeld: COMCAD - Center on Migration, Citizenship and Development; 2010.Meanwhile, immigrant integration is one ...
Gerdes, Jürgen
core +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Österreichisches Religionspädagogisches Forum, 2016 ENGLISH: The integration of Muslim migrants has become a major issue in public debates in various European countries, among them Austria. The debates comprise political, social, and also pedagogical questions.
Christian Feichtinger
doaj
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
[Consensus paper for the standardized laboratory diagnostics of chronic kidney disease (CKD) in the context of cardiovascular-renal-metabolic health (ÖGLMKC, ÖQUASTA, ÖGN) : Consensus paper of the Austrian Society for Laboratory Medicine and Clinical Chemistry (ÖGLMKC), the Austrian Society for Quality Assurance and Standardization of Medical Diagnostic Examinations (ÖQUASTA), and the Austrian Society for Nephrology (ÖGN)]. [PDF]
Wien Klin WochenschrEller K +10 more
europepmc +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Timely Integration of specialist palliative care into oncology care for patients receiving radiotherapy for bone metastases: A study procotol for the TIPZO-RT Randomized Controlled Trial. [PDF]
PLoS Onevan Oss A +9 more
europepmc +1 more source