Results 91 to 100 of about 6,167,674 (361)

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

open access: yesFEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg   +2 more
wiley   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

open access: yesFEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro   +2 more
wiley   +1 more source

In vivo evidence for glycyl radical insertion into a catalytically inactive variant of pyruvate formate‐lyase

open access: yesFEBS Letters, EarlyView.
Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel   +2 more
wiley   +1 more source

Current progress in the derivation and therapeutic application of neural stem cells

open access: yesCell Death and Disease, 2017
Neural stem cells (NSCs) have a unique role in neural regeneration. Cell therapy based on NSC transplantation is a promising tool for the treatment of nervous system diseases.
Yuewen Tang, Pei Yu, Lin Cheng
semanticscholar   +1 more source

DERIVATIONS AND SKEW DERIVATIONS OF THE GRASSMANN ALGEBRAS [PDF]

open access: yesJournal of Algebra and Its Applications, 2009
Surprisingly, skew derivations rather than ordinary derivations are more basic (important) object in study of the Grassmann algebras. Let Λn = K ⌊x1, …, xn⌋ be the Grassmann algebra over a commutative ring K with ½ ∈ K, and δ be a skew K-derivation of Λn.
openaire   +3 more sources

DERIVATIVES OF EUGENOL. [PDF]

open access: yesJournal of the American Chemical Society, 1897
n ...
Pond, F. J., Beers, F. T.
openaire   +2 more sources

P‐glycoprotein modulates the fluidity gradient of the plasma membrane of multidrug resistant CHO cells

open access: yesFEBS Letters, EarlyView.
To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche   +2 more
wiley   +1 more source

The scrypt Password-Based Key Derivation Function

open access: yesRequest for Comments, 2016
This document specifies the password-based key derivation function scrypt. The function derives one or more secret keys from a secret string. It is based on memory-hard functions, which offer added protection against attacks using custom hardware.
Colin Percival, S. Josefsson
semanticscholar   +1 more source

On derivations and generalized derivations of bitonic algebras

open access: yesApplicable Analysis and Discrete Mathematics, 2018
We introduce the notion of bitonic algebras as a generalization of dual BCCalgebras, and define the notion of (r,l)-derivations, (l,r)-derivations and generalized (r,l) and (l,r)-derivations on the bitonic algebras. Then we study the properties of the derivations and the generalized derivations on the bitonic algebras and the commutative ...
Yon, Y.H., Ayar Ozbal, S.
openaire   +4 more sources

Evolutionary interplay between viruses and R‐loops

open access: yesFEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi   +4 more
wiley   +1 more source

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