Current progress in the derivation and therapeutic application of neural stem cells
Neural stem cells (NSCs) have a unique role in neural regeneration. Cell therapy based on NSC transplantation is a promising tool for the treatment of nervous system diseases.
Yuewen Tang, Pei Yu, Lin Cheng
semanticscholar +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
LEXICALIZATION IN MORPHOLOGY: A CASE STUDY OF THE ANTICAUSATIVE PREFIX IN TAQBAYLIT BERBER [PDF]
What makes lexicalization an intriguing topic in morphology? It is not so much the semantic mismatch between a base and its ‘derived’ form, but the question of how lexicalization is underlyingly represented.
Amazigh Bedar
doaj
Time after time – circadian clocks through the lens of oscillator theory
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Generalized Derivations With Left Annihilator Conditions in Prime and Semiprime Rings
Let R be a prime ring with its Utumi ring of quotients U, C = Z(U) be the extended centroid of R, H and G two generalized derivations of R, L a noncentral Lie ideal of R, I a nonzero ideal of R.
Dhara Basudeb
doaj +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Этимологические заметки о русском семинарском жаргоне: ВЗЪЕФАНТУЛИТЬ, СМОРОЗИТЬ, АКСИОС(Ы) (= Some Etymological Notes on the Russian Seminarian Slang: VZʺEFANTULITʹ, SMOROZITʹ, AKSIOS(Y)) [PDF]
Три отдельные заметки объединены тем, что рассмотренные в них слова происходят из русского семинарского жаргона и являются грецизмами, причём в двух первых случаях неочевидными, каламбурными.
Игорь Георгиевич Добродомов
doaj
Define generalized commutators for a ring \(R\) by \([x,y]_ 1 = xy - yx\) and for \(k > 1\) set \([x,y]_ k = [[x,y]_{k - 1},y]\), where \(x,y \in R\). The author proves that if \(R\) has no nonzero nil ideal and has a derivation \(D\) satisfying \([D(x^ n),x^ n]_ k = 0\) for \(k \geq 1\), all \(x\in R\), and \(n = n(x) \geq 1\), then the Utumi quotient
openaire +2 more sources
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source

