Results 101 to 110 of about 120,136 (269)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Derivation of machine learning brain aging biomarkers for a set of forty thousand functional connectomes

Brain Research Bulletin
Various Magnetic Resonance Imaging modalities were developed to explore the brain. Among them, functional MRI is of key importance for studying brain activity and its neural substrates.
Nicolas Honnorat, Di Wang, Ngoc-Huynh Ho, David Martinez, Sachintha Ransara Brandigampala, Susan R. Heckbert, Mohsen Bahrami, Jayandra Jung Himali, Charlie DeCarli, Alexa Beiser, Timothy M. Hughes, Sudha Seshadri, Mohamad Habes   +12 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Development and validation of a novel nomogram to predict aneurysm rupture in patients with multiple intracranial aneurysms: a multicentre retrospective study

Stroke and Vascular Neurology
Background and purpose Approximately 15%–45% of patients with unruptured intracranial aneurysms have multiple intracranial aneurysms (MIAs). Determining which one is most likely to rupture is extremely important for treatment decision making for MIAs ...
Yang Zhao, Jun Lu, Peng Qi, Daming Wang, Yuanli Zhao, Aihua Liu, Xin Tong, Xin Feng, Fei Peng, Hao Niu, Weitao Jin, Zhongxue Wu   +11 more
doaj   +1 more source

Characterizing derivatives by preimages of sets

, 1999
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +2 more sources

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Development of a predictive model for long-term care and support eligibility certification associated with dementia-related functional impairments: the IRIDE cohort study

BMC Public Health
Background The Long-Term Care Insurance (LTCI) system in Japan provides a framework for assessing dementia-related functional decline, enabling the development of predictive models based on daily functional independence.
Daichi Yamashiro, Hiroyuki Suzuki, Susumu Ogawa, Mari Yamashita, Hiroki Moriya, Hiroyuki Sasai, Shuichi P. Obuchi, Takumi Abe, Hiroshi Murayama, Takumi Hirata, Yoshinori Fujiwara, Shuichi Awata, Masahiro Akishita, Kenji Toba, IRIDE Cohort Study Investigators   +14 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source