Results 121 to 130 of about 117,485 (309)
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Applied General Topology, 2013 Let $G$ be a group, $\mathcal{P}_G$ be the family of all subsets of $G$. For a subset $A\subseteq G$, we put $\Delta(A)=\{g\in G:|gA\cap A|=\infty\}$.
Igor V. Protasov
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Model and risk score performance: derivation set (n = 247) and validation set (n = 247).
, 2013 Abbreviations: TP, number of true positives; FP, number of false positives; FN, number of false negatives; TN, number of true negatives; Se, sensitivity; Sp, specificity; PPV, positive predictive value; NPV, negative predictive value; Acc, rate of ...
Chiara Cattaneo (155742) +12 more
core +1 more source
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Heat Map of a Derivation Set, Comprised of Verified Cases and Inflamed Controls.
, 2016 This heat map, built on agglomerative clustering with linkage by mean and a Euclidian distance metric, shows a comparison of log(2)-transformed normalized gene expression data from blood. Rows represent individual genes, the symbols of which are shown at
Michael R. Filbin (3133722) +8 more
core +1 more source
α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates
FEBS Letters, EarlyView.Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino +2 more
wiley +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
A class of Buekenhout unitals in the Hall plane
, 1996 Let U be the classical unital in PG(2, q2) secant to ℓ∞. By deriving PG(2, q2) with respect to a derivation set disjoint from U we obtain a new unital U′ in the Hall plane of order q2.
Barwick, S.
core +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source