Results 121 to 130 of about 959,671 (288)

Development and validation of a novel nomogram to predict aneurysm rupture in patients with multiple intracranial aneurysms: a multicentre retrospective study

open access: yesStroke and Vascular Neurology
Background and purpose Approximately 15%–45% of patients with unruptured intracranial aneurysms have multiple intracranial aneurysms (MIAs). Determining which one is most likely to rupture is extremely important for treatment decision making for MIAs ...
Yang Zhao   +11 more
doaj   +1 more source

Level Sets of Derivatives [PDF]

open access: yesTransactions of the American Mathematical Society, 1982
openaire   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Development of a predictive model for long-term care and support eligibility certification associated with dementia-related functional impairments: the IRIDE cohort study

open access: yesBMC Public Health
Background The Long-Term Care Insurance (LTCI) system in Japan provides a framework for assessing dementia-related functional decline, enabling the development of predictive models based on daily functional independence.
Daichi Yamashiro   +14 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Research Quality and Newsworthiness of Published Articles are Partial Predictors of Journal Impact Factors. A Review of: Lokker, C., Haynes, R. B., Chu, R., McKibbon, K. A., Wilczynski, N. L., & Walter, S. D. (2012). How well are journal and clinical article characteristics associated with the journal impact factor?A retrospective cohort study. Journal of the Medical Library Association, 100(1), 28-33. doi:10.3163/1536-5050.100.1.006

open access: yesEvidence Based Library and Information Practice, 2012
Objective – Determine what characteristics ofa journal’s published articles can be used topredict the journal impact factor (JIF).Design – A retrospective cohort study.Setting – The researchers are located atMcMaster University, Hamilton, Ontario,Canada ...
Jason Martin
doaj  

On the Structural Behavior of Multiplicative (Generalized)-Derivations via d-Algebra Structures

open access: yesJournal of Mathematics
In the context of a d-algebra structure ℧,∗,0, this paper aims to introduce the concept of a multiplicative (generalized)-derivation G associated with a self-map Ξ (not necessarily a derivation).
Hicham Saber   +4 more
doaj   +1 more source

A DSL-based Approach to Product Derivation for Software Product Line

open access: yesActa Informatica Pragensia, 2016
Product derivation is an important part of the Software Product Line (SPL) development process. The quality of a product derivation process has a direct impact in decreasing software product costs and time-to-market. In this paper, we present an approach
Nesrine Lahiani, Djamal Bennouar
doaj   +1 more source

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