Results 141 to 150 of about 117,485 (309)

Age-adjusted d-dimer cut-off levels increase the clinical utility of ruling out pulmonary embolism in elderly patients

, 2009
Background: The D-Dimer (DD) test, used to rule out pulmonary embolism (PE), is less useful in elderly patients due to a lower specificity. We retrospectively derived and validated the efficacy of an age- dependent DD cut-off combined with clinical ...
Büller, H.R., Perrier, A., Righini, M., Kamphuisen, P.W., Roy, P.M., Douma, R.A., Söhne, M., Bounameaux, H., Kruip, M.J.H.A., Le Gal, G.   +9 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Development of a predictive model for long-term care and support eligibility certification associated with dementia-related functional impairments: the IRIDE cohort study

BMC Public Health
Background The Long-Term Care Insurance (LTCI) system in Japan provides a framework for assessing dementia-related functional decline, enabling the development of predictive models based on daily functional independence.
Daichi Yamashiro, Hiroyuki Suzuki, Susumu Ogawa, Mari Yamashita, Hiroki Moriya, Hiroyuki Sasai, Shuichi P. Obuchi, Takumi Abe, Hiroshi Murayama, Takumi Hirata, Yoshinori Fujiwara, Shuichi Awata, Masahiro Akishita, Kenji Toba, IRIDE Cohort Study Investigators   +14 more
doaj   +1 more source

Identification of a predominant COPD phenotype in clinical practice

, 2008
SummaryBackgroundChronic obstructive pulmonary disease (COPD) is characterized by airflow limitation caused by small airways increased resistance and/or terminal airspaces emphysematous destruction.
Camiciottoli, Gianna, Eleonora Meoni, Marmai, Cecilia, Paoletti, Matteo, Massimo Pistolesi, Pistolesi, Massimo, Gianna Camiciottoli, Cecilia Marmai, Giuntini, Carlo, Carlo Giuntini, Carlo Marchesi, Marchesi, Carlo, Matteo Paoletti, Federico Lavorini, Lavorini, Federico, Meoni, Eleonora   +15 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A DSL-based Approach to Product Derivation for Software Product Line

Acta Informatica Pragensia, 2016
Product derivation is an important part of the Software Product Line (SPL) development process. The quality of a product derivation process has a direct impact in decreasing software product costs and time-to-market. In this paper, we present an approach
Nesrine Lahiani, Djamal Bennouar
doaj   +1 more source

Characterizing derivatives by preimages of sets

, 1999
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +2 more sources

On the Structural Behavior of Multiplicative (Generalized)-Derivations via d-Algebra Structures

Journal of Mathematics
In the context of a d-algebra structure ℧,∗,0, this paper aims to introduce the concept of a multiplicative (generalized)-derivation G associated with a self-map Ξ (not necessarily a derivation).
Hicham Saber, Zakia Z. Al-Amery, Radwan M. Al-Omary, Khaled Aldwoah, Ria Egami   +4 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source