Results 131 to 140 of about 117,485 (309)

Potential of an age adjusted D-dimer cut-off value to improve the exclusion of pulmonary embolism in older patients: A retrospective analysis of three large cohorts

, 2010
Objectives: In older patients, the the D-dimer test for pulmonary embolism has reduced specificity and is therefore less useful. In this study a new, age dependent cut-off value for the test was devised and its usefulness with older patients assessed ...
Righini, M., Kamphuisen, PW, Roy, Pierre-Marie, Bounameaux, H. (Henri), Gal, G., Righini, M. (Marc), Le Gal, Grégoire, M.J.H.A. Kruip, Kruip, M.J.H.A., Kruip, M. J., Buller, HR, Douma, RA, Roy, P. M., M. Righini, Kamphuisen, Pieter W, G. Le Gal, Douma, R.A., H. Bounameaux, Righini, Marc, Kruip, Marieke J. H. A., Kamphuisen, Pieter W., Douma, R.A. (Renée), Kamphuisen, P.W. (Pieter Willem), Büller, Harry R., Bounameaux, H, Perrier, A, M. Sohne, Bounameaux, Henri, P.W. Kamphuisen, Büller, H.R., Büller, Harry R, P.M. Roy, Söhne, M., Righini, Marc Philip, Söhne, M. (Maaike), Righini, M, Roy, PM, Perrier, Arnaud, le Gal, G., Le Gal, G. (Grégoire), Perrier, A. (Arnaud), A. Perrier, Douma, Renée A., Gal, G, Roy, P.M., Bounameaux, H., H.R. Büller, Kruip, Marieke J H A, Büller, H.R. (Harry), Douma, Renée A, Sohne, M, Kruip, M.J.H.A. (Marieke), Buller, H. R., R.A. Douma, Söhne, Maaike, Perrier, A., Kamphuisen, P.W., Kruip, Marieke, Kamphuisen, P. W.   +58 more
core   +2 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

On the set where an approximate derivative is a derivative [PDF]

Colloquium Mathematicum, 1980
Pu, H. H., Pu, H. W.
openaire   +2 more sources

DIRECTIONAL DERIVATIVES IN SET OPTIMIZATION WITH THE SET LESS ORDER RELATION

Taiwanese Journal of Mathematics, 2015
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +3 more sources

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Derivation of machine learning brain aging biomarkers for a set of forty thousand functional connectomes

Brain Research Bulletin
Various Magnetic Resonance Imaging modalities were developed to explore the brain. Among them, functional MRI is of key importance for studying brain activity and its neural substrates.
Nicolas Honnorat, Di Wang, Ngoc-Huynh Ho, David Martinez, Sachintha Ransara Brandigampala, Susan R. Heckbert, Mohsen Bahrami, Jayandra Jung Himali, Charlie DeCarli, Alexa Beiser, Timothy M. Hughes, Sudha Seshadri, Mohamad Habes   +12 more
doaj   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Development and validation of a novel nomogram to predict aneurysm rupture in patients with multiple intracranial aneurysms: a multicentre retrospective study

Stroke and Vascular Neurology
Background and purpose Approximately 15%–45% of patients with unruptured intracranial aneurysms have multiple intracranial aneurysms (MIAs). Determining which one is most likely to rupture is extremely important for treatment decision making for MIAs ...
Yang Zhao, Jun Lu, Peng Qi, Daming Wang, Yuanli Zhao, Aihua Liu, Xin Tong, Xin Feng, Fei Peng, Hao Niu, Weitao Jin, Zhongxue Wu   +11 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source