Results 81 to 90 of about 117,485 (309)
Cytokines predictive of immunological set-point levels. (A–E)
, 2012 Cytokine concentrations in plasma at M0 have been plotted against CD4+ T cell counts and T cell activation (CD3+CD8+CD38+HLA-DR+) at M6. Six patients, including 4 who were treated at M6, were excluded from the analysis at M6.
Béatrice Jacquelin (130327) +12 more
core +1 more source
Western Journal of Emergency Medicine, 2017 Introduction: Endotracheal intubation (ETI) in the prehospital setting poses unique challenges where multiple ETI attempts are associated with adverse patient outcomes.
Jestin N. Carlson +4 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
, 2011 BACKGROUND/AIMS: Treating a group of chronic hepatitis B virus (HBV)-infected patients with high viral load and advanced fibrosis or cirrhosis, regardless of their serum alanine aminotransferase (ALT) levels, is recommended.
Yang, JM +9 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Development of a New Nomogram Including Neutrophil-to-Lymphocyte Ratio to Predict Survival in Patients with Hepatocellular Carcinoma Undergoing Transarterial Chemoembolization [PDF]
, 2019 The neutrophil-to-lymphocyte ratio (NLR) has recently been reported to predict the prognosis of hepatocellular carcinoma (HCC). We explored whether NLR predicted the survival of patients with HCC undergoing transarterial chemoembolization (TACE), and ...
Hye Kyung Hyun +13 more
core +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Lattices of Irreducibly-derived Closed Sets
Electronic Notes in Theoretical Computer Science, 2019 Abstract This paper pursues an investigation on the lattices of irreducibly-derived closed sets initiated by Zhao and Ho (2015). This time we focus the closed set lattice arising from the irreducibly-derived topology of Scott topology. For a poset X, the set Γ S I ( X ) of all irreducibly-derived Scott-closed sets (for short, SI ...
Shuhua Su, Qi Li
openaire +1 more source
Screening for significant chronic liver disease by using three simple ultrasound parameters
, 2015 Objectives Chronic liver diseases remain asymptomatic for many years. Consequently, patients are diagnosed belatedly, when cirrhosis is unmasked by lifethreatening complications.
Oberti, Frédéric +13 more
core +2 more sources
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source