Results 71 to 80 of about 117,485 (309)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Development and validation of clinical prediction models to distinguish influenza from other viruses causing acute respiratory infections in children and adults - Fig 3

, 2019
Comparison of ROC curves among the two different models, GEE and classification tree, for the prediction of influenza A/B in adults (a. derivation set; b. validation set).
Pardeep Singh (294895), Dominik Mertz (88663), Eleanor Pullenayegum (426635), Danielle Vuichard-Gysin (6321254), Mark Loeb (248712), Marek Smieja (117473)   +5 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Derivation and internal validation of prediction models for pulmonary hypertension risk assessment in a cohort inhabiting Tibet, China

eLife
Individuals residing in plateau regions are susceptible to pulmonary hypertension (PH) and there is an urgent need for a prediction nomogram to assess the risk of PH in this population. A total of 6603 subjects were randomly divided into a derivation set
Junhui Tang, Rui Yang, Hui Li, Xiaodong Wei, Zhen Yang, Wenbin Cai, Yao Jiang, Ga Zhuo, Li Meng, Yali Xu   +9 more
doaj   +1 more source

Development and validation of clinical prediction models to distinguish influenza from other viruses causing acute respiratory infections in children and adults - Fig 2

, 2019
Comparison of ROC curves among the two different models, GEE and classification tree, for the prediction of influenza A/B I children (a. derivation set; b. validation set).
Pardeep Singh (294895), Dominik Mertz (88663), Eleanor Pullenayegum (426635), Danielle Vuichard-Gysin (6321254), Mark Loeb (248712), Marek Smieja (117473)   +5 more
core   +1 more source

patients

, 2023
International audienceAbstract Sustained viral response (SVR) significantly improves the prognosis in patients with hepatitis C virus (HCV) chronic infection but does not totally alleviate the risk of liver‐related complications (LRC).
Canivet, Clémence, Jérémie Riou, Etienne Audureau, Lusivika-Nzinga, Clovis, Clémence Moreau, Moreau, Clémence, Fabrice Carrat, Clémence M. Canivet, Jérôme Boursier, Carrat, Fabrice, Riou, Jérémie, Boursier, Jérôme, Clovis Lusivika‐Nzinga, Roux, Marine, Baumert, Thomas, F, Nahon, Pierre, Audureau, Etienne, Marine Roux, Pierre Nahon   +18 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

New scoring system for predicting percutaneous coronary intervention of chronic total occlusion success: Impact of operator’s experience

, 2023
Background: Several scoring systems have been developed in order to predict percutaneous coronary intervention (PCI) result of chronic total occlusion (CTO). The scores principally include anatomic and clinical variables.
Fuertes, Mónica; Interventional Cardiology Unit, Cardiology Division, Joan XXIII University Hospital, Pere Virgili Health Research Institute (IISPV), Tarragona, Spain, Zambrano, Diego; Interventional Cardiology Unit, Cardiology Division, Joan XXIII University Hospital, Pere Virgili Health Research Institute (IISPV), Tarragona, Spain, Guarinos, Jordi; Interventional Cardiology Unit, Cardiology Division, Joan XXIII University Hospital, Pere Virgili Health Research Institute (IISPV), Tarragona, Spain, Pernigotti, Alberto; Interventional Cardiology Unit, Cardiology Division, Joan XXIII University Hospital, Pere Virgili Health Research Institute (IISPV), Tarragona, Spain, Moreno, Cristina; Interventional Cardiology Unit, Cardiology Division, Joan XXIII University Hospital, Pere Virgili Health Research Institute (IISPV), Tarragona, Spain, Doblas, Victor; Interventional Cardiology Unit, Cardiology Division, Joan XXIII University Hospital, Pere Virgili Health Research Institute (IISPV), Tarragona, Spain, Mohandes, Mohsen; Interventional Cardiology Unit, Cardiology Division, Joan XXIII University Hospital, Pere Virgili Health Research Institute (IISPV), Tarragona, Spain, Fernández, Francisco; Interventional Cardiology Unit, Cardiology Division, Joan XXIII University Hospital, Pere Virgili Health Research Institute (IISPV), Tarragona, Spain, Bardají, Alfredo; Cardiology Division, Joan XXIII Univer sity Hospital, Pere Virgili Health Research Insitute (IISPV), Tarragona, Spain, Rojas, Sergio; Interventional Cardiology Unit, Cardiology Division, Joan XXIII University Hospital, Pere Virgili Health Research Institute (IISPV), Tarragona, Spain   +9 more
core   +3 more sources

On the range of nth order derivations acting on commutative Banach positive squares ℓ-algebras

Topological Algebra and its Applications, 2015
In this paper we prove that the image of a nth order derivation on real commutative Banach ℓ-algebras with positive squares is contained in the set of nilpotent elements.
Kouki Naoual, Toumi Mohamed Ali
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source