Results 121 to 130 of about 641,705 (295)

A derivative-free optimization method for solving classification problem

, 2010
Problem statement: The aim of data classification is to establish rules for the classification of some observations assuming that we have a database, which includes of at least two classes. There is a training set for each class.
Abu Hassan, Malik, Shabanzadeh, Parvaneh, Leong, Wah June   +2 more
core   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Invariant-free deduction for CTL*: the tableau method

, 2010
We define a classical style, one-pass tableau for the full branching-time logic CTL?. This work extends previously defined tableau technique for propositional linear-time temporal logic, PLTL, giving a new decision procedure for CTL?.
Lucio, P., Bolotov, A., Gaintzarain, J.
core  

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

unified approach to the construction of higher-order derivative-free iterative methods for solving systems of nonlinear equations

Proceedings of the Mongolian Academy of Sciences
In this article, we introduce a unified approach to constructing a higher-order derivative-free scheme based on the approximations of F'(zk)-1. A family of order  p=6,7 derivative-free method is proposed and compared to some well-known methods.
Tugal Zhanlav, Khuder Otgondorj, Renchin-Ochir Mijiddorj, Lkhagvadash Saruul   +3 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Impact of fractional and integer order derivatives on the (4+1)-dimensional fractional Davey–Stewartson–Kadomtsev–Petviashvili equation

Partial Differential Equations in Applied Mathematics
In this study, the closed-form wave solutions of the (4+1)-dimensional fractional Davey–Stewartson–Kadomtsev–Petviashvili equation are investigated using the modified auxiliary equation method and the Jacobi elliptic function method. In the analysis, two
Adil Jhangeer, Haiqa Ehsan, Muhammad Bilal Riaz, Abdallah M. Talafha   +3 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source