Results 91 to 100 of about 17,151,919 (277)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Derivative-Free Optimization [PDF]

, 2020
. In many engineering applications it is common to find optimization problems where the cost function and/or constraints require complex simulations.
David Echeverría Ciaurri, Slawomir Koziel, Oliver Kramer   +2 more
core  

unified approach to the construction of higher-order derivative-free iterative methods for solving systems of nonlinear equations

Proceedings of the Mongolian Academy of Sciences
In this article, we introduce a unified approach to constructing a higher-order derivative-free scheme based on the approximations of F'(zk)-1. A family of order  p=6,7 derivative-free method is proposed and compared to some well-known methods.
Tugal Zhanlav, Khuder Otgondorj, Renchin-Ochir Mijiddorj, Lkhagvadash Saruul   +3 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

A derivative-free approach for large scale problems [PDF]

, 2022
Questa tesi si propone di illustrare e testare l'efficacia di un nuovo algoritmo per la risoluzione di problemi a larga scala senza l'utilizzo di ...
Roselli, Michele
core  

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Some Iterative Methods Free from Derivatives and Their Basins of Attraction for Nonlinear Equations

Discrete Dynamics in Nature and Society, 2013
First, we make the Jain's derivative-free method optimal and subsequently increase its efficiency index from 1.442 to 1.587. Then, a novel three-step computational family of iterative schemes for solving single variable nonlinear equations is given.
Farahnaz Soleimani, Fazlollah Soleymani, Stanford Shateyi   +2 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

A class of derivative-free trust-region methods with interior backtracking technique for nonlinear optimization problems subject to linear inequality constraints

Journal of Inequalities and Applications, 2018
This paper focuses on a class of nonlinear optimization subject to linear inequality constraints with unavailable-derivative objective functions. We propose a derivative-free trust-region methods with interior backtracking technique for this optimization.
Jing Gao, Jian Cao
doaj   +1 more source