Results 81 to 90 of about 17,151,919 (277)
A General Class of Derivative Free Optimal Root Finding Methods Based on Rational Interpolation
The Scientific World Journal, 2015 We construct a new general class of derivative free n-point iterative methods of optimal order of convergence 2n-1 using rational interpolant. The special cases of this class are obtained.
Fiza Zafar +3 more
doaj +1 more source
Trust-Region Methods for the Derivative-Free Optimization of Nonsmooth Black-Box Functions
SIAM Journal on Optimization, 2019 In this paper we study the minimization of a nonsmooth black-box type function, without assuming any access to derivatives or generalized derivatives and without any knowledge about the analytical ...
G. Liuzzi +3 more
semanticscholar +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Discrete and Continuous Models and Applied Computational ScienceIn this paper, we develop a new family of high-order derivative-free iterative methods for solving systems of nonlinear equations. Specifically, we propose four two-step derivative-free schemes with convergence orders four and five, together with twelve ...
Tugal Zhanlav +3 more
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Derivative-free optimization and neural networks for robust regression
, 2012 Large outliers break down linear and nonlinear regression models. Robust regression methods allow one to filter out the outliers when building a model.
Gleb Beliakov (13071387) +2 more
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Derivative-Free Pattern Search Methods for Multidisciplinary Design Problems
, 1994 There have been interesting recent developments in methods for solving optimization problems without making use of derivative (sensitivity) information.
J. E. Dennis, Jr. +4 more
core +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source