Results 81 to 90 of about 305,961 (299)
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
A Hybrid Direct Search and Model-Based Derivative-Free Optimization Method with Dynamic Decision Processing and Application in Solid-Tank Design [PDF]
, 2023 Zhongda Huang +5 more
openalex +1 more source
On Derivative-Free Optimisation Methods
, 2023 As part of the field of mathematical optimisation, derivative-free optimisation is the study of optimisation methods that are not granted full access to the derivative of the objective function. In this master's thesis, three derivative-free optimisation methods known from the literature that do not use the derivatives have been studied, namely the ...
openaire +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Some Iterative Methods Free from Derivatives and Their Basins of Attraction for Nonlinear Equations
Discrete Dynamics in Nature and Society, 2013 First, we make the Jain's derivative-free method optimal and subsequently increase its efficiency index from 1.442 to 1.587. Then, a novel three-step computational family of iterative schemes for solving single variable nonlinear equations is given.
Farahnaz Soleimani +2 more
doaj +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Journal of Inequalities and Applications, 2018 This paper focuses on a class of nonlinear optimization subject to linear inequality constraints with unavailable-derivative objective functions. We propose a derivative-free trust-region methods with interior backtracking technique for this optimization.
Jing Gao, Jian Cao
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The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Algorithms for Molecular Biology, 2018 Background A profile-comparison method with position-specific scoring matrix (PSSM) is among the most accurate alignment methods. Currently, cosine similarity and correlation coefficients are used as scoring functions of dynamic programming to calculate ...
Kazunori D. Yamada
doaj +1 more source