Results 51 to 60 of about 17,151,919 (277)
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Loneliness is associated with adverse physical and mental health outcomes and remains understudied in children and adolescents undergoing cancer therapy. Pediatric oncology patients may be at increased risk due to medical isolation and disruption of social networks.
Charlotte N. Stahlfeld +5 more
wiley +1 more source
Derivative-Free Optimization of Noisy Functions via Quasi-Newton Methods [PDF]
SIAM Journal on Optimization, 2018 This paper presents a finite difference quasi-Newton method for the minimization of noisy functions. The method takes advantage of the scalability and power of BFGS updating, and employs an adaptive procedure for choosing the differencing interval $h ...
A. Berahas, R. Byrd, J. Nocedal
semanticscholar +1 more source
Central Nervous System Tumors Among Infants in Canada: A Report From CYP‐C
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Central nervous system (CNS) tumors in infants are rare, pose unique clinical challenges, and lack large‐scale evidence‐based data to guide management. This study seeks to describe CNS tumors in Canadian infants and to compare their outcomes with those of older children.
Samuel Sassine +17 more
wiley +1 more source
Three-Step Derivative-Free Method of Order Six
Foundations, 2023 Derivative-free iterative methods are useful to approximate the numerical solutions when the given function lacks explicit derivative information or when the derivatives are too expensive to compute.
Sunil Kumar +3 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) is an essential therapy for several malignant and nonmalignant diseases, but relapse and graft loss remain the principal threats to its success. Routine monitoring of chimerism and minimal residual disease (MRD) enables early detection of imminent recurrence and guides ...
Carmen Junk +10 more
wiley +1 more source
Derivative-Free Optimization for Low-Rank Adaptation in Large Language Models [PDF]
IEEE/ACM Transactions on Audio Speech and Language ProcessingParameter-efficient tuning methods such as LoRA could achieve comparable performance to model tuning by tuning a small portion of the parameters. However, substantial computational resources are still required, as this process involves calculating ...
Fei-Hu Jin, Yifan Liu, Ying Tan
semanticscholar +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman +9 more
wiley +1 more source
Survey of trust-region derivative free optimization methods
, 2007 In this survey article we give the basic description of the interpolation based derivative free optimization methods and their variants. We review the recent contributions dealing with maintaining the geometry of the interpolation set, the management of ...
Karasözen, Bülent
core +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Pediatric intramedullary low‐grade gliomas (PIMLGGs) are rare neoplasms that present unique clinical and management challenges. Although surgery remains the primary tool for tissue diagnosis and decompression, complete gross‐total resection is frequently unfeasible due to the infiltrative nature of these lesions.
Olga M. Sergeenko +5 more
wiley +1 more source
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Patients with chronic kidney disease undergoing hemodialysis commonly experience reduced physical function, fatigue, poor sleep quality, and impaired health‐related quality of life. Intradialytic exercise has been proposed as a non‐pharmacological strategy to improve these outcomes.
Klebson da Silva Almeida +6 more
wiley +1 more source