Results 81 to 90 of about 1,072,002 (279)

A General Class of Derivative Free Optimal Root Finding Methods Based on Rational Interpolation

open access: yesThe Scientific World Journal, 2015
We construct a new general class of derivative free n-point iterative methods of optimal order of convergence 2n-1 using rational interpolant. The special cases of this class are obtained.
Fiza Zafar   +3 more
doaj   +1 more source

Challenges with bearings only tracking for missile guidance systems and how to cope with them. [PDF]

open access: yes, 2010
This paper addresses the problem of closed loop missile guidance using bearings and target angular extent information. Comparison is performed between particle filtering methods and derivative free methods.
Mihaylova, Lyudmila   +2 more
core  

On Derivative-Free Optimisation Methods

open access: yes, 2023
As part of the field of mathematical optimisation, derivative-free optimisation is the study of optimisation methods that are not granted full access to the derivative of the objective function. In this master's thesis, three derivative-free optimisation methods known from the literature that do not use the derivatives have been studied, namely the ...
openaire   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Systems and Methods for Derivative-Free Adaptive Control [PDF]

open access: yes
An adaptive control system is disclosed. The control system can control uncertain dynamic systems. The control system can employ one or more derivative-free adaptive control architectures. The control system can further employ one or more derivative-free
Calise, Anthony J.   +2 more
core   +1 more source

Metric-Free Natural Gradient for Joint-Training of Boltzmann Machines [PDF]

open access: yes, 2013
This paper introduces the Metric-Free Natural Gradient (MFNG) algorithm for training Boltzmann Machines. Similar in spirit to the Hessian-Free method of Martens [8], our algorithm belongs to the family of truncated Newton methods and exploits an ...
Bengio, Yoshua   +3 more
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

A Family of Derivative-Free Conjugate Gradient Methods for Constrained Nonlinear Equations and Image Restoration

open access: yesIEEE Access, 2020
In this paper, a derivative-free conjugate gradient method for solving nonlinear equations with convex constraints is proposed. The proposed method can be viewed as an extension of the three-term modified Polak-Ribiére-Polyak method (TTPRP) and ...
Abdulkarim Hassan Ibrahim   +2 more
doaj   +1 more source

Optimizing Photonic Nanostructures via Multi-fidelity Gaussian Processes [PDF]

open access: yes, 2018
We apply numerical methods in combination with finite-difference-time-domain (FDTD) simulations to optimize transmission properties of plasmonic mirror color filters using a multi-objective figure of merit over a five-dimensional parameter space by ...
Atwater, Harry A.   +6 more
core   +1 more source

Home - About - Disclaimer - Privacy