Results 41 to 50 of about 21,039 (262)
DERIVATIVE FINANCIAL INSTRUMENTS AS RISK HEDGING
, 2022 The article discusses the problems of the development of derivative financial instruments in the global economy. The analysis of the current state of the exchange and over-the-counter markets of derivative financial instruments is carried out. The legal regulation of the derivatives market in international and Russian banking practice is considered ...
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Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
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Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
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THE EFFECT OF DERIVATIVE FINANCIAL INSTRUMENTS ON BANK RISKS, RELEVANCE AND FAITHFUL REPRESENTATION: EVIDENCE FROM BANKS IN HUNGARY [PDF]
Annals of the University of Oradea: Economic Science, 2014 In a continuously changing business environment accounting data have to provide useful information in order to achieve relevant and faithful representation in financial statements.
Toth Kornel, , ,
doaj
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
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La determinazione del fair value di opzioni su valuta impiegando funzioni a base radiale: un’applicazione al framework di pricing di Garman-Kohlhagen [PDF]
Risk Management Magazine, 2019 Garman – Kohlhagen framework, which is an extension of the most popular Black-Scholes-Merton model, is often used by financial institutions in order to price options with a currency as underlying. These pricing techniques have in common the definition of
Simone Fioribello +1 more
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Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
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Weather Derivatives: A New Class of Financial Instruments [PDF]
SSRN Electronic Journal, 2003 This paper is a concise introduction of the weather derivatives market. We present a brief survey of the market, describe the main products, and illustrate their usage in risk management. We also discuss the key issues in modeling and valuation. Finally, taking weather derivatives as an alternative asset class, we demonstrate their potentials in asset ...
Melanie Cao +2 more
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