Results 61 to 70 of about 254,951 (334)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

DEVELOPMENT OF DERIVATIVE MARKET IN 2000-2012

Vestnik MGIMO-Universiteta, 2014
At the end of XIX century futures exchange emerged, in the early 70-ies XX century - option exchange of financial derivatives. These exchanges gave a huge boost to the development of market of the operations with derivative financial instruments. In fact,
Evgeniya V. Vasina
doaj   +5 more sources

Do Derivatives Instruments Ownership Decrease Firm Value in Indonesia?

Riset Akuntansi dan Keuangan Indonesia, 2020
This research aims to examine the association between derivatives instruments and firm value. This research is quantitative research with multiple linear regression models and panel data.
Amrie Firmansyah, Eko Bayu Dian Purnama
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

“ANALISIS PENGARUH DEBT TO EQUITY RATIO, FINANCIAL DISTRESS, FIRM SIZE, GROWTH OPPORTUNITY, INSTITUTIONAL OWNERSHIP DAN LIQUIDITY TERHADAP PENGAMBILAN KEPUTUSAN HEDGING MENGGUNAKAN INSTRUMEN DERIVATIF (Studi pada Perusahaan Manufaktur dan Perusahaan ESDM yang Terdaftar di BEI Periode 2010-2014)” [PDF]

, 2016
Hedging is one of the alternatives of risk management that aims to protect assets of company from losses caused by the risk. The purpose of this research is to analyze the influence of independent variables which include DER, Financial Distress, Firm ...
PANGESTUTI, Irene Rini Demi, WIRYAWAN, Yosafat Aditya   +1 more
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

FINANCIAL FUNCTION GUIDANCE IN RISK MANAGEMENT

Acta Economica, 2005
Financial policy represents the guidance for decision-making process about fundamental financial goals in a company. We accomplish it with the financial management. One of financial functions goals is financial risk exposure reduction.
Jožko Peterlin, PhD
doaj  

FINANCIAL ANALYSIS FOR TRANSACTION WITH FINANCIAL TOOLS AT OMV PETROM CITY ROMANIA [PDF]

Annals of the University of Petrosani: Economics, 2017
Through this paper the authors approach the sphere of financial instruments on the capital market. Their conceptual evolution is influenced by both the relationship between the accounting and financial approach and the degree of use for financial ...
ILIE RĂSCOLEAN, ILEANA-SORINA RAKOS
doaj  

A Brief Analysis of Derivative Financial Instrument Accounting and China's Countermeasures

, 2019
In recent years, with the rapid development of China's economy, derivative financial instruments are more widely used in China's enterprises. This paper studies the accounting for derivative financial instruments, which brings great challenges and risks ...
Jiaying Zheng
semanticscholar   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source