Results 51 to 60 of about 160,637 (306)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

FINANCIAL FUNCTION GUIDANCE IN RISK MANAGEMENT

open access: yesActa Economica, 2005
Financial policy represents the guidance for decision-making process about fundamental financial goals in a company. We accomplish it with the financial management. One of financial functions goals is financial risk exposure reduction.
Jožko Peterlin, PhD
doaj  

FINANCIAL ANALYSIS FOR TRANSACTION WITH FINANCIAL TOOLS AT OMV PETROM CITY ROMANIA [PDF]

open access: yesAnnals of the University of Petrosani: Economics, 2017
Through this paper the authors approach the sphere of financial instruments on the capital market. Their conceptual evolution is influenced by both the relationship between the accounting and financial approach and the degree of use for financial ...
ILIE RĂSCOLEAN, ILEANA-SORINA RAKOS
doaj  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

Swaps and financial derivatives: risks and returns

open access: yesPSL Quarterly Review, 2013
Derivative financial products have experienced a huge expansion during recent years. New products are constantly appearing which seek to expand the scope of risk diversification.
R.S. MASERA
doaj   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

open access: yesFEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava   +3 more
wiley   +1 more source

Swap e prodotti derivati: rischi e rendimenti

open access: yesMoneta e Credito, 2013
Derivative financial products have experienced a huge expansion during recent years. New products are constantly appearing which seek to expand the scope of risk diversification.
R.S. MASERA
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Institutional and regulatory aspects of implementation of financial instruments for risk management in the Republic of Serbia [PDF]

open access: yesEkonomija: teorija i praksa, 2019
This paper presents an analysis of institutional and regulatory framework for the implementation of a new group of financial instruments for risk management purposes that should enable faster economic development of the Republic of Serbia.
Dimitrov Filip   +2 more
doaj  

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