Results 51 to 60 of about 90,046 (266)

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Analysis of Quantum Multiplicative Calculus and Related Inequalities

Mathematics
This article investigates the exact meaning of a quantum derivative result and the corresponding definition of a quantum definite integral in multiplicative calculus from a geometrical viewpoint.
Muhammad Nasim Aftab, Saad Ihsan Butt, Mohammed Alammar, Youngsoo Seol   +3 more
doaj   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Starfish Optimization-Based Fractional Order 3DoF Control Strategy for Enhanced Frequency Stability in RES-Based Microgrids

IEEE Access
Frequency stability in microgrids presents vital challenges owing to unpredictable load variations and intermittent Renewable Energy Sources (RESs). This study investigates enhanced Load Frequency Control methodologies to address stability challenges ...
Imran Khan, Suheel Abdullah Malik, Amil Daraz, Muhammad Majid Gulzar, Baitullah Bareer   +4 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Performance Analyses of Four-Instant Discretization Formulas With Application to Generalized-Sylvester-Type Future Matrix Equation

IEEE Access, 2019
For solving generalized-Sylvester-type future matrix equation (GS-type FME) effectively, the continuous zeroing neural network (ZNN) model should be discretized by appropriate discretization formula.
Zhangqiang Yin, Kang Liu, Yuanhang Chen, Rui Xue, Jian Li, Yang Shi   +5 more
doaj   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Existence and Attractivity of Mild Solutions for Fractional Diffusion Equations Involving the Regularized ψ-Hilfer Fractional Derivatives

Axioms
The regularized ψ-Hilfer derivative within the sense of Caputo is an improved version of the ψ-Hilfer fractional derivative, primarily because it addresses the issue where the initial conditions of problems involving the ψ-Hilfer fractional derivative ...
Luyao Wang, Yuhang Jin, Wenchang He, Jia Mu   +3 more
doaj   +1 more source