Second-order mollified derivatives and optimization [PDF]
The class of strongly semicontinuous functions is considered. For these functions the notion of mollified derivatives, introduced by Ermoliev, Norkin and Wets, is extended to the second order.
Rocca Matteo +2 more
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Spirooxindole Derivatives as Emerging Scaffolds in Drug Discovery: Synthetic Strategies, Structure-Activity Relationship, and Biological Activities. [PDF]
ChemMedChemKalita RC, Bezbaruah S, Patle D.
europepmc +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Estimating the Payoffs of Temperature-based Weather Derivatives [PDF]
Temperature-based weather derivatives are written on an index which is normally defined to be a nonlinear function of average daily temperatures. Recent empirical work has demonstrated the usefulness of simple time-series models of temperature for ...
Adam Clements, K A Lindsay, A S Hurn
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New antifungal and less toxic zwitterionic derivatives of 26-membered polyene antibiotic - pimaricin containing <i>N</i>-benzyl and <i>N</i>-alkyl moieties and their molecular mechanism. [PDF]
J Enzyme Inhib Med ChemSmolarz E +8 more
europepmc +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
The Impact of Institutional Differences on Derivatives Usage: A Comparative Study of US and Dutch Firms [PDF]
This paper tests the influence of institutional differences on risk management practices.Several survey studies have investigated derivatives usage for risk management purposes in the US (see, among others, Bodnar, Hayt, Marston and Smithson, 1995 and ...
Jong, A. de, Macrae, V., Bodnar, G.M.
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Design, synthesis, drug-likeness, and molecular dynamics evaluations of monobrominated amathamide G analogs as potential ligands for D2-like dopamine receptors. [PDF]
In Silico PharmacolNavarrete-Gutiérrez A +5 more
europepmc +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Eriosema glomeratum Possessed Interesting Bioactive Constituents and Semisynthetic Derivatives With Relevant Biosynthetic Correlation and Important Chemophenetic Significance. [PDF]
Chem BiodiversTabakam GT, Awouafack MD.
europepmc +1 more source