Results 241 to 250 of about 1,355,285 (310)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Sulfonamide-Based 2-Amino-1,3,4-Oxadiazole Derivatives as Dual Cholinesterase and Carbonic Anhydrase Inhibitors: Design, Synthesis, Kinetic Characterization, Molecular Modeling, and ADMET Evaluation. [PDF]

Drug Dev Res
Arslan Karahan G, Gökçe B, Muhammed MT, Ayan EK, Özçelik AB.   +4 more
europepmc   +1 more source

Recent Progress in Urea-Containing Compounds as Tyrosine Kinase Inhibitors. [PDF]

Chem Biodivers
Sroor FM.
europepmc   +1 more source

Gut microbiome-derived indoles differentially suppress type III secretion system-associated virulence in <i>Escherichia coli</i> and <i>Salmonella enterica</i>. [PDF]

Front Microbiol
Shvarthburg M, Taussig D, Even-Tov N, Wine Y, Sal-Man N.   +4 more
europepmc   +1 more source

Heterocyclic-Based Fungicides: Emerging Strategies for Viable Plant Disease Control. [PDF]

Chem Biodivers
Tahlan S, Kaira M, Singh S, Dey H, Pandey KC.   +4 more
europepmc   +1 more source

Rational Design of Multifunctional Tacrine Derivatives as Candidates for the Treatment of Alzheimer and Parkinson Diseases. [PDF]

ChemMedChem
Dzib E, Hernández-Ayala LF, Silva-Aguirre S, Galano A.   +3 more
europepmc   +1 more source

An investigation of 2-hydrazinyl-1,3-benzothiazole, 4-amino-4H-1,2,4-triazole and 2-hydrazinyl-1H-benzimidazole applicability as derivatization reagents for HPLC-HRMS determination of steroid hormones in urine. [PDF]

Front Chem
Zorina M, Feng YQ, Atapattu SN, Dotsenko V, Kindop V, Afonin M, Zhu QF, Temerdashev A.   +7 more
europepmc   +1 more source