Results 261 to 270 of about 1,196,568 (318)

Research advances in the application of betulinic acid for anti-inflammatory and anti-tumour therapy. [PDF]

Chin Med
Chu Z, Jiang S, Li Y, Li X, Koh WX, Aruncharoenphonchai P, Ding Y, Xiang Y.   +7 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Synthesis and Bioactivity Studies of Benzimidazole-Chalcone Hybrids. [PDF]

Molecules
Makgoathana HD, Mthembu ST, Mhlanga TV, Selepe MA, Sonopo MS.   +4 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Distribution and bioactivities of tirucallane-type triterpenoids from Meliaceae family. [PDF]

Nat Prod Bioprospect
Abdullah FF, Putri SA, Najihah NA, Nurlelasari, Safriansyah W, Awang K, Supratman U.   +6 more
europepmc   +1 more source

Mitochondria-targeting organoselenium theranostic radioprotectors for simultaneous treatment and imaging of radiation-induced liver injury. [PDF]

Theranostics
Wu Z, Huang X, Gao M, Wang L, Du Z, Shang Z, Yu X, Wang X, Deng S, Yang X, Lu B, Liu J, Wang W, Li R, Luo S.   +14 more
europepmc   +1 more source

Synthesis and Evaluation of Novel Cinnamic Acid Hybrids With Antiacetylcholinesterase, Antioxidant, and Anti-Inflammatory Properties. [PDF]

ChemMedChem
Sdougkou K, Rekka E, Papagiannopoulou D.
europepmc   +1 more source

Structure-Activity Relationship and Stage-Dependent Inhibition of Adipogenesis by Curcuminoid Derivatives in 3T3-L1 Cells. [PDF]

Nutrients
Araki S, Ueda Y, Ayabe H, Otsuka R, Kohama K, Maenishi K, Choi C, Moon SK, Masuda T, Deguchi M, Saeki S, Kim D.   +11 more
europepmc   +1 more source

Corrigendum to "Evaluation of molecular mechanisms of (Z)-3-(pentadec-10'-enyl)-catechol (litreol) and synthetic derivatives as inhibitors of human leukotriene biosynthesis" [Redox Biol. 87 (2025) 103880]. [PDF]

Redox Biol
Cossu AM, Pace S, Bruno F, Abbatiello L, Cerchia C, Falbo E, Ramírez ACM, Kretzer C, Miek L, Troisi F, Gerstmeier J, Ambrosino P, Zappavigna S, Lavecchia A, Werz O, Caraglia M, Filosa R.   +16 more
europepmc   +1 more source