Results 191 to 200 of about 1,910,776 (311)

Linking existing in vitro dermal absorption data to physicochemical properties: Contribution to the design of a weight-of-evidence approach for the safety evaluation of cosmetic ingredients with low dermal bioavailability.

Regulatory toxicology and pharmacology : RTP, 2016
G. Ateş, Fabian P. Steinmetz, T. Doktorova, J. Madden, V. Rogiers   +4 more
semanticscholar   +1 more source

All‐Flex Plasma Patch for In Vivo Delivery of Reactive Species

Advanced Science, EarlyView.
A fully flexible plasma patch enables stable, conformal treatment on complex biological surfaces and enhances transdermal delivery of reactive species. This platform achieves significant tumor suppression in vivo and reveals coordinated regulation of calcium signaling, metabolism, and programmed cell death, providing a promising strategy for safe and ...
Luxiang Zhao, Abulaihaiti Tuergong, Hanshu Yang, Shuang Xue, An Yan, Mingzhen Wang, Weilong Song, Wenzhe Si, Ruixue Wang   +8 more
wiley   +1 more source

Role of clothing in both accelerating and impeding dermal absorption of airborne SVOCs

Journal of Exposure Science and Environmental Epidemiology, 2016
G. Morrison, C. Weschler, G. Bekö, H. Koch, T. Salthammer, T. Schripp, J. Toftum, G. Clausen   +7 more
semanticscholar   +1 more source

Inside‐Outside ROS Therapeutic Strategy Based on Piezoelectric Nano‐Urchin for Drug‐Resistant Bacteria Biofilm Infections

Advanced Science, EarlyView.
The contribution of this study lies not only in enabling effective treatment of drug‐resistant biofilm infections, but also in establishing a transferable therapeutic paradigm: Ultrasound‐triggered mechanical forces synergistically enhance piezoelectric polarization and nanozyme activity, driving functional ROS generation inside and outside biofilms ...
Xinjian Guo, Jin Yang, Mengjie An, Bingjie Lin, Tao Liu, Limin Zhang   +5 more
wiley   +1 more source

High-throughput PBK modelling for dermal exposure: a pragmatic approach to predict systemic pharmacokinetics. [PDF]

Arch Toxicol
Edizcan Z, Schaller S, Kuepfer L, Geci R.   +3 more
europepmc   +1 more source

Membrane Fusion‐Mediated Cytosolic Delivery of Threose Nucleic Acids via Homotypic Nanoparticles Overcomes Drug Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study introduces a biomimetic “nanofusion” platform that integrates the biostability of threose nucleic acids (TNA) with homotypic cell‐membrane cloaking to combat drug‐resistant TNBC. By leveraging a non‐canonical membrane‐fusion pathway for direct cytosolic delivery, the platform bypasses endosomal sequestration. To achieve potent AKT2 silencing
Wei Zheng, Tristan Juin Han Chang, Xinchao Li, Zhongqi Zhou, Chung Tin, Kenward Vong, Pierre Karam, Pik Kwan Lo   +7 more
wiley   +1 more source

Engineering skin microphysiological systems for transdermal drug screening based on strategic model selection and quantitative prediction roadmaps. [PDF]

Mater Today Bio
Ahn J, Jin G, Cho M, Do M, Ahn J, Ko J, Bang S.   +6 more
europepmc   +1 more source

p300 Degradation by the p53‐SIAH1 Axis Relieves TBK1 Acetylation to Enhance Innate Antiviral Immunity

Advanced Science, EarlyView.
This study identifies p300 as the acetyltransferase that acetylates TBK1 and inhibits its phosphorylation. Activation of the p53‐SIAH1 axis by immune response downregulates p300 expression to sustain innate antiviral immunity. Conditional p300 knockout in alveolar epithelial cells in vivo promotes antiviral responses and suppresses virus replication ...
Huidi Yu, Zhihao Zhan, Xiaoxiang Pan, Xinyue Zhang, Penggang Liu, Jing Sun, Xiulong Xu   +6 more
wiley   +1 more source

Fatal pediatric paraquat poisoning following scalp application for head lice treatment: Public health implications for pesticide regulation and emergency care - A case series. [PDF]

Toxicol Rep
Solomon A, Omachi PA, Eze EC, Ahmed G, Ojewole OE, Oyeleye AE, Abdullahi U, Mammud A, Abdullahi H, Idris ZF, Idris U, Abubakar U.   +11 more
europepmc   +1 more source

Comparison of international guidelines of dermal absorption tests used in pesticides exposure assessment for operators. [PDF]

Toxicol Res, 2014
So J, Ahn J, Lee TH, Park KH, Paik MK, Jeong M, Cho MH, Jeong SH.   +7 more
europepmc   +1 more source