Results 201 to 210 of about 35,060 (247)

DERMAL ABSORPTION OF HEXACHLOROPHANE IN INFANTS

The Lancet, 1971
Abstract Hexachlorophane is widely used as Summary an antibacterial agent. It has been reported that repeated high oral doses of hexachlorophane (25 mg. per kg. per day) in rats produced paralysis and a pronounced œdema of the white-matter of the central nervous system. To see whether hexachlorophane may be absorbed through the intact infant skin,
A, Curley, R D, Kimbrough, R E, Hawk, G, Nathenson, L, Finberg   +4 more
openaire   +2 more sources

Pharmacokinetic models of dermal absorption

Journal of Pharmaceutical Sciences, 2001
Many studies have used pharmacokinetic (compartment) models for skin to predict or analyze dermal absorption of chemicals. Comparing these models is difficult because the relationships between rate constants and the physicochemical parameters were not always defined clearly, simplifying assumptions built into models sometimes were not stated, and which
K D, McCarley, A L, Bunge
openaire   +2 more sources

Dermal Absorption of Pesticide Residues

Chemical Research in Toxicology, 2018
Current guidance for dermal exposure assessment of plant protection products typically uses in vitro skin penetration data for the active ingredient when applied as both the concentrated product and relevant spray dilutions thereof. However, typical re-entry scenarios involve potential skin exposure to a "dried residue" of the spray dilution, from ...
James F. Clarke, Sarah F. Cordery, Neil A. Morgan, Peter K. Knowles, Richard H. Guy   +4 more
openaire   +2 more sources

Dermal Absorption Model

2022
Presentation to ISES on Sept. 25-29, 2022 in Lisbon, Portugal Science Inventory, CCTE products: https://cfpub.epa.gov/si/si_public_search_results.cfm?advSearch=true&showCriteria=2&keyword=CCTE&TIMSType=&TIMSSubTypeID=&epaNumber=&ombCat=Any&dateBeginPublishedPresented=07/01/2017&dateEndPublishedPresented=& ...
Fisher, HA, Evans, MV, Eklund, CR, Vallero, Daniel, Bunge, A, Cohen Hubal, Elaine   +5 more
openaire   +1 more source

Assessing Dermal Absorption

Toxicological Sciences, 2000
The article highlighted in this issue is "Comparative in Vitro-in Vivo Percutaneous Absorption of the Pesticide Propoxur" by Johannes J. M. van de Sandt, Wim J. A. Meuling, Graham R. Elliott, Nicole H. P. Cnubben, and Betty C. Hakkert (pp 15-22).
openaire   +2 more sources

Dermal absorption of chlorpyrifos in human volunteers

International Archives of Occupational and Environmental Health, 2004
The methods and results are described of a study on the dermal absorption of chlorpyrifos (CPF) in humans established via urinary excretion of the metabolite 3,5,6-trichloro-2-pyridinol (TCP).Two dermal, single, doses of CPF were applied in two study groups (A and B) each comprising three apparently healthy male volunteers who gave their written ...
Meuling, W.J., Ravensberg, L.C., Roza, L., Hemmen, J.J. van   +3 more
openaire   +3 more sources

Dermal Absorption of Pesticides in the Rat

AIHAJ - American Industrial Hygiene Association, 2000
The Office of Pesticide Programs (OPP) of the Environmental Protection Agency has developed a standard protocol for evaluating the dermal penetration of pesticides in the rat. This protocol was formalized in 1994 as a guideline for Dermal Absorption Studies of Pesticides.
openaire   +2 more sources

Dermal absorption of niclosamide in rats and minipigs

Biopharmaceutics & Drug Disposition, 1991
AbstractThe dermal absorption of niclosamide, a drug shown to prevent Schistosomiasis by blocking the dermal penetration of cercariae, has been examined in Sinclair minipigs and rats. Radioactivity in the urine and feces collected daily for 7 days after application of 14C‐niclosamide accounted for less than 2 per cent and 10 per cent of the labelled ...
P, Brennan, D, Johnson, S, Rider, N, Cone, M, Goldman, A, Buckpitt, H, Chung   +6 more
openaire   +2 more sources

Percutaneous Absorption and Dermal Delivery of Cyclosporin A

Journal of Pharmaceutical Sciences, 1995
The present study deals with attempts to deliver cyclosporin A into the deeper skin and some of the fundamental reasons why this proves so difficult. Because of different physicochemical requirements for the solution and activity of cyclosporin A and the enhancer, n-decylmethyl sulfoxide, it was hard to demonstrate increases in permeation of ...
H K, Choi, G L, Flynn, G L, Amidon
openaire   +2 more sources

Dermal Absorption of Phthalate Diesters in Rats

Toxicological Sciences, 1989
This study examined the extent of dermal absorption of a series of phthalate diesters in the rat. Those tested were dimethyl, diethyl, dibutyl, diisobutyl, dihexyl, di(2-ethylhexyl), diisodecyl, and benzyl butyl phthalate. Hair from a skin area (1.3 cm in diameter) on the back of male F344 rats was clipped, the [14C]phthalate diester was applied in a ...
A E, Elsisi, D E, Carter, I G, Sipes
openaire   +2 more sources