Results 221 to 230 of about 1,062,941 (282)

Evaluating Neutral PFAS for Potential Dermal Absorption from the Gas Phase

Environmental Science & Technology, 2023
Exposures to per- and polyfluoroalkyl substances (PFAS) are of increasing concern. Assessments typically focus only on ingestion and inhalation exposure due to a lack of generally accepted approaches for estimating dermal absorption. Prior work indicates
Jennifer Field, Ivan A Titaley, Derek J Muensterman   +2 more
exaly   +2 more sources

Relative absorption and dermal loading of chemical substances: Consequences for risk assessment

Regulatory Toxicology and Pharmacology, 2009
Quantification of skin absorption is an essential step in reducing the uncertainty of dermal risk assessment. Data from literature indicate that the relative dermal absorption of substances is dependent on dermal loading.
Harrie Buist, Johannes J M van de Sandt, Gerwin Schaafsma   +2 more
exaly   +1 more source

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On the Dermal Absorption of Cocaine

Journal of Analytical Toxicology, 1990
A 5-mg dose of cocaine free base applied to the volar forearm skin surface of a volunteer resulted in a maximal urinary benzoylecgonine concentration of 55 ng/mL at 48 h, using discrete urine specimens. A total of 58 micrograms of benzoylecgonine, representing 1.2% of the dose, was excreted in the 96-h urine.
R C, Baselt, J Y, Chang, D M, Yoshikawa
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Dermal absorption of dihalomethane vapors

Toxicology and Applied Pharmacology, 1985
The dermal absorption of dibromomethane (DBM) and bromochloromethane (BCM) vapors was studied in rats placed in a specially designed chamber incorporating individual respiratory protection to avoid pulmonary uptake. Exposures (DBM: 500 to 10,000 ppm; BCM: 2500 to 40,000 ppm) lasted 4 hr during which time five blood samples were drawn from jugular ...
J N, McDougal, G W, Jepson, H J, Clewell, M E, Andersen   +3 more
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DERMAL ABSORPTION OF HEXACHLOROPHANE IN INFANTS

The Lancet, 1971
Abstract Hexachlorophane is widely used as Summary an antibacterial agent. It has been reported that repeated high oral doses of hexachlorophane (25 mg. per kg. per day) in rats produced paralysis and a pronounced œdema of the white-matter of the central nervous system. To see whether hexachlorophane may be absorbed through the intact infant skin,
A, Curley, R D, Kimbrough, R E, Hawk, G, Nathenson, L, Finberg   +4 more
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Pharmacokinetic models of dermal absorption

Journal of Pharmaceutical Sciences, 2001
Many studies have used pharmacokinetic (compartment) models for skin to predict or analyze dermal absorption of chemicals. Comparing these models is difficult because the relationships between rate constants and the physicochemical parameters were not always defined clearly, simplifying assumptions built into models sometimes were not stated, and which
K D, McCarley, A L, Bunge
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Dermal Absorption of Pesticide Residues

Chemical Research in Toxicology, 2018
Current guidance for dermal exposure assessment of plant protection products typically uses in vitro skin penetration data for the active ingredient when applied as both the concentrated product and relevant spray dilutions thereof. However, typical re-entry scenarios involve potential skin exposure to a "dried residue" of the spray dilution, from ...
James F. Clarke, Sarah F. Cordery, Neil A. Morgan, Peter K. Knowles, Richard H. Guy   +4 more
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Dermal Absorption Model

2022
Presentation to ISES on Sept. 25-29, 2022 in Lisbon, Portugal Science Inventory, CCTE products: https://cfpub.epa.gov/si/si_public_search_results.cfm?advSearch=true&showCriteria=2&keyword=CCTE&TIMSType=&TIMSSubTypeID=&epaNumber=&ombCat=Any&dateBeginPublishedPresented=07/01/2017&dateEndPublishedPresented=& ...
Fisher, HA, Evans, MV, Eklund, CR, Vallero, Daniel, Bunge, A, Cohen Hubal, Elaine   +5 more
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