Results 231 to 240 of about 1,062,941 (282)

Assessing Dermal Absorption

Toxicological Sciences, 2000
The article highlighted in this issue is "Comparative in Vitro-in Vivo Percutaneous Absorption of the Pesticide Propoxur" by Johannes J. M. van de Sandt, Wim J. A. Meuling, Graham R. Elliott, Nicole H. P. Cnubben, and Betty C. Hakkert (pp 15-22).
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Dermal absorption of niclosamide in rats and minipigs

Biopharmaceutics & Drug Disposition, 1991
AbstractThe dermal absorption of niclosamide, a drug shown to prevent Schistosomiasis by blocking the dermal penetration of cercariae, has been examined in Sinclair minipigs and rats. Radioactivity in the urine and feces collected daily for 7 days after application of 14C‐niclosamide accounted for less than 2 per cent and 10 per cent of the labelled ...
P, Brennan, D, Johnson, S, Rider, N, Cone, M, Goldman, A, Buckpitt, H, Chung   +6 more
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Dermal Absorption of Pesticides in the Rat

AIHAJ - American Industrial Hygiene Association, 2000
The Office of Pesticide Programs (OPP) of the Environmental Protection Agency has developed a standard protocol for evaluating the dermal penetration of pesticides in the rat. This protocol was formalized in 1994 as a guideline for Dermal Absorption Studies of Pesticides.
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Percutaneous Absorption and Dermal Delivery of Cyclosporin A

Journal of Pharmaceutical Sciences, 1995
The present study deals with attempts to deliver cyclosporin A into the deeper skin and some of the fundamental reasons why this proves so difficult. Because of different physicochemical requirements for the solution and activity of cyclosporin A and the enhancer, n-decylmethyl sulfoxide, it was hard to demonstrate increases in permeation of ...
H K, Choi, G L, Flynn, G L, Amidon
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Uncertainty in Measurements of Dermal Absorption of Pesticides

Risk Analysis, 2002
Dermal absorption experiments form an important component in the assessment of risk from exposure to pesticides and other substances. Much dermal absorption data is gathered in rat experiments carried out using a certain standard protocol. Uncertainties in these data arise from many sources and can be quite large.
William C, Navidi, Annette L, Bunge
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Dermal Absorption of Phthalate Diesters in Rats

Toxicological Sciences, 1989
This study examined the extent of dermal absorption of a series of phthalate diesters in the rat. Those tested were dimethyl, diethyl, dibutyl, diisobutyl, dihexyl, di(2-ethylhexyl), diisodecyl, and benzyl butyl phthalate. Hair from a skin area (1.3 cm in diameter) on the back of male F344 rats was clipped, the [14C]phthalate diester was applied in a ...
A E, Elsisi, D E, Carter, I G, Sipes
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Dermal absorption of pesticides calculated by deconvolution

Journal of Applied Toxicology, 1985
AbstractUsing published human data on skin‐to‐urine and blood‐to‐urine transfer of 12 pesticides and herbicides, the skin‐to‐blood transfer rates for each compound were estimated by two numerical deconvolution techniques. Regular constrained deconvolution produced an estimated upper limit on cumulative dermal absorption of the radiolabel, while ...
H L, Fisher, B, Most, L L, Hall
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Dermal absorption of inorganic germanium in rats

Regulatory Toxicology and Pharmacology, 2008
So-called germanium 'health' products including dietary supplements, cosmetics, accessories, and warm bath service containing germanium compounds and metalloid are popular in Japan. Subchronic and chronic oral exposure of germanium dioxide (GeO(2)), popular chemical form of inorganic germanium causes severe germanium toxicosis including death and ...
Katsuhiko, Yokoi, Takae, Kawaai, Aki, Konomi, Yuka, Uchida   +3 more
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Dermal absorption of chlorpyrifos in human volunteers

International Archives of Occupational and Environmental Health, 2004
The methods and results are described of a study on the dermal absorption of chlorpyrifos (CPF) in humans established via urinary excretion of the metabolite 3,5,6-trichloro-2-pyridinol (TCP).Two dermal, single, doses of CPF were applied in two study groups (A and B) each comprising three apparently healthy male volunteers who gave their written ...
Meuling, W.J., Ravensberg, L.C., Roza, L., Hemmen, J.J. van   +3 more
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Mathematical models for dermal drug absorption

Expert Opinion on Drug Metabolism & Toxicology, 2015
Mathematical models of dermal transport offer the advantages of being much faster and less expensive than in vitro or in vivo studies. The number of methods used to create such models has been increasing rapidly, probably due to the steady rise in computational power.
Dominik, Selzer, Dirk, Neumann, Ulrich F, Schaefer   +2 more
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