Results 251 to 260 of about 75,603 (294)

Dermal absorption of chlorpyrifos in human volunteers

International Archives of Occupational and Environmental Health, 2004
The methods and results are described of a study on the dermal absorption of chlorpyrifos (CPF) in humans established via urinary excretion of the metabolite 3,5,6-trichloro-2-pyridinol (TCP).Two dermal, single, doses of CPF were applied in two study groups (A and B) each comprising three apparently healthy male volunteers who gave their written ...
Meuling, W.J., Ravensberg, L.C., Roza, L., Hemmen, J.J. van   +3 more
openaire   +3 more sources

Dermal absorption of permethrin following topical administration

European Journal of Clinical Pharmacology, 2005
Permethrin is an insecticide used in the treatment of lice and scabies infections. Although its efficacy and safety have been well documented, pharmacokinetic data are sparse. The objective of this study was to determine the systemic exposure of permethrin and the duration of residence in the human body following topical administration.The study ...
D, Tomalik-Scharte, A, Lazar, J, Meins, B, Bastian, M, Ihrig, B, Wachall, A, Jetter, I, Tantcheva-Poór, G, Mahrle, U, Fuhr   +9 more
openaire   +2 more sources

Multilayered Dermal Subcompartments for Modeling Chemical Absorption

SAR and QSAR in Environmental Research, 1996
Dermal penetration of chemicals and drugs is of concern to both toxicologists and pharmacologists. Environmental professionals try to limit exposure to chemicals using protective clothing and gloves or barrier creams to trap chemicals. Drug developers try to enhance penetration of chemicals through the skin for medical purposes. Both can use predictive
R L, Bookout, C R, McDaniel, D W, Quinn, J N, McDougal   +3 more
openaire   +2 more sources

Dermal absorption of inorganic germanium in rats

Regulatory Toxicology and Pharmacology, 2008
So-called germanium 'health' products including dietary supplements, cosmetics, accessories, and warm bath service containing germanium compounds and metalloid are popular in Japan. Subchronic and chronic oral exposure of germanium dioxide (GeO(2)), popular chemical form of inorganic germanium causes severe germanium toxicosis including death and ...
Katsuhiko, Yokoi, Takae, Kawaai, Aki, Konomi, Yuka, Uchida   +3 more
openaire   +2 more sources

Dermal absorption of pesticides calculated by deconvolution

Journal of Applied Toxicology, 1985
AbstractUsing published human data on skin‐to‐urine and blood‐to‐urine transfer of 12 pesticides and herbicides, the skin‐to‐blood transfer rates for each compound were estimated by two numerical deconvolution techniques. Regular constrained deconvolution produced an estimated upper limit on cumulative dermal absorption of the radiolabel, while ...
H L, Fisher, B, Most, L L, Hall
openaire   +2 more sources

Experimental Methods for Determining Permethrin Dermal Absorption

Journal of Toxicology and Environmental Health, Part A, 2011
The objectives of this study were to (1) determine the percutaneous absorption of radiolabeled permethrin and piperonyl butoxide (PBO) in vivo in rats and in vitro to permit a calculation of the ratio of in vitro to in vivo values, and (2) test a method of estimating in vivo human absorption. Carbon-14 labeled permethrin in ethanol solution was applied
William G, Reifenrath, John H, Ross, Jeffrey H, Driver   +2 more
openaire   +2 more sources

DERMAL ABSORPTION OF VITAMIN D

Archives of Pediatrics & Adolescent Medicine, 1935
The purpose of this study was to determine whether the skin is capable of absorbing vitamin D in sufficient amounts to prevent and to cure experimental rickets. A study of the literature shows a paucity of available information as regards the absorption of vitamin D through the skin.
openaire   +1 more source

Dermal Absorption of Pesticides in the Rat

AIHAJ - American Industrial Hygiene Association, 2000
The Office of Pesticide Programs (OPP) of the Environmental Protection Agency has developed a standard protocol for evaluating the dermal penetration of pesticides in the rat. This protocol was formalized in 1994 as a guideline for Dermal Absorption Studies of Pesticides.
openaire   +2 more sources

[Dermal exposure and absorption].

Giornale italiano di medicina del lavoro ed ergonomia, 2011
Dermal exposure assessment explores the dynamic interaction between environmental contaminants and the skin. The measure of skin exposure can be made using direct methods (interception techniques, removal techniques from skin, in situ detection) or indirect methods (biological monitoring, removal techniques from surfaces).
openaire   +1 more source

Dermal Absorption and Toxicity Assessment

2007
The relationship between structure and barrier function of skin dermal metabolism systemic toxicity in man secondary to percutaneous absorption. Part 1 Modelling of dermal risk assessment: occupational skin disease - a case study current issues inthe in vitro measurement of percutaneous absorption investigation of the skin permeation in vitro ...
openaire   +1 more source