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Dermal absorption of pesticides in mice
Pesticide Biochemistry and Physiology, 1985Abstract The dermal penetration of 2,4-D, cyhexatin, fenvalerate, paraquat, maleic hydrazide, and captan was determined at 1, 6, and 24 hr after application to a 1.2-cm2 area of the upperback of 7- to 8-week-old mice (1 mg/kg). The amounts of labeled pesticide were measured at the site of application and in the blood, liver, kidney, excreta, and ...
R.E. Grissom, C. Brownie, F.E. Guthrie
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Gastrointestinal and Dermal Absorption: Interspecies Differences
Drug Metabolism Reviews, 1984It has been repeatedly demonstrated that there are considerable interspecies differences with respect to the dermal absorptions of a chemically diverse set of substances, ranging from ionic substances to complex organic molecules, some of which are of great relevance to environmental/occupational health (e.g., the organophosphate insecticides).
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2010
The focus of this chapter is on modeling the absorption of chemical pollutants into and across human skin. The skin is a primary route of systemic exposure to a number of environmental pollutants either directly as neat chemicals, in aqueous solution when exposure is to polluted water, or in complex solvents when exposure occurs secondary to contact at
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The focus of this chapter is on modeling the absorption of chemical pollutants into and across human skin. The skin is a primary route of systemic exposure to a number of environmental pollutants either directly as neat chemicals, in aqueous solution when exposure is to polluted water, or in complex solvents when exposure occurs secondary to contact at
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Dermal absorption of PCB in man
Chemosphere, 1992Abstract In a controlled experiment simulating the accidental contact with PCB and thus the dermal absorption a uniformly labeled 13C-PCB mixture was applied to the skin of a volunteer. Blood samples were collected after the application and the concentrations of 13C-PCBs determined using GC/MS.
P. Schmid, F. Bühler, Ch. Schlatter
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Dermal Absorption of Peptides and Proteins
1993Historically, the skin was viewed as an impermeable barrier. However, in recent years, it has been increasingly recognized that intact skin can be used as a port for continuous systemic administration of drugs. The first transdermal drug delivery system which has used this new concept is a scopolamine-releasing transdermal therapeutic system (Transderm-
Ajay K. Banga, Yie W. Chien
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[Dermal exposure and absorption].
Giornale italiano di medicina del lavoro ed ergonomia, 2011Dermal exposure assessment explores the dynamic interaction between environmental contaminants and the skin. The measure of skin exposure can be made using direct methods (interception techniques, removal techniques from skin, in situ detection) or indirect methods (biological monitoring, removal techniques from surfaces).
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DERMAL ABSORPTION OF VITAMIN D
Archives of Pediatrics & Adolescent Medicine, 1935The purpose of this study was to determine whether the skin is capable of absorbing vitamin D in sufficient amounts to prevent and to cure experimental rickets. A study of the literature shows a paucity of available information as regards the absorption of vitamin D through the skin.
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Dermal absorption of fenitrothion in rat
Bulletin of Environmental Contamination and Toxicology, 1974J D, Kohli, M Z, Hasan, B N, Gupta
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Dermal Absorption and Toxicity Assessment
2007The relationship between structure and barrier function of skin dermal metabolism systemic toxicity in man secondary to percutaneous absorption. Part 1 Modelling of dermal risk assessment: occupational skin disease - a case study current issues inthe in vitro measurement of percutaneous absorption investigation of the skin permeation in vitro ...
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