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Immunologic properties of human dermal fibroblasts
Human Immunology, 2010Human dermal fibroblasts are known not to express human leukocyte antigen (HLA)-DR message or protein in the absence of interferon (IFN)-γ. To use allogeneic dermal fibroblasts for cell therapy, as a revalidation, the cells at passage 12 were analyzed for HLA-DR mRNA and surface protein.
Manisha, Deshpande +5 more
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Chondrogenic Differentiation of Adult Dermal Fibroblasts
Annals of Biomedical Engineering, 2004Cell sources for generation of articular cartilage ex vivo are limited. To explore options other than stem cells, dermal fibroblasts were tested for their developmental potential when cultured on the cartilage matrix proteoglycan, aggrecan. A previous study suggested such an effort would be successful (M. M.
M M, French +3 more
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Experimental Gerontology, 1991
One approach to understanding the relationship between in vitro cellular senescence and in vivo aging is to define the development and aging of cells in vivo and then to compare these in vivo properties with the in vitro behavior of the same cells.
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One approach to understanding the relationship between in vitro cellular senescence and in vivo aging is to define the development and aging of cells in vivo and then to compare these in vivo properties with the in vitro behavior of the same cells.
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Isolation and Culture of Human Dermal Fibroblasts
2019Dermal fibroblasts are the main cell type present in skin connective tissue (dermis). Fibroblasts interact with epidermal cells during hair development and in interfollicular skin. Moreover, they play an essential role during cutaneous wound healing and in bioengineering of skin. Hence, culture of primary fibroblast is gaining in importance.
Kisiel MA, Klar AS
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Fibroblasts and Dermal Gene Therapy: A Minireview
Human Gene Therapy, 2000This review highlights our current understanding of the biology of, survival of, and transgene expression by genetically modified fibroblasts (GMFb) carrying stably integrated transgenes in vivo. Experimental data demonstrate that three elements will enhance expression by and survival of GMFb in vivo: a matrix scaffolding to take the place of the ...
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Epidermal Regulation of Dermal Fibroblast Activity
Plastic and Reconstructive Surgery, 1998Although the association between delayed burn wound healing and subsequent hypertrophic scar formation is well-established, the mechanism for this relationship is unknown. Unhealed burn wounds lack an epidermis, suggesting a possible regulatory role for the epidermis in controlling dermal fibroblast matrix synthesis.
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Stimulation of Human Dermal Fibroblasts with Interleukin 2
Journal of Burn Care & Rehabilitation, 1991The role of soluble inflammatory mediators in the wound healing process is under investigation. Interleukin 2 (IL2), an immune modulator produced by T lymphocytes, was tested in vitro for its effects on human diploid fibroblasts. Human diploid fibroblasts (1.0 x 10(4)) were incubated for 24 hours in Alpha minimal essential media (Gibco Laboratories ...
A, Abdullah, R L, McCauley, D N, Herndon
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Quantification of Single Human Dermal Fibroblast Contraction
Tissue Engineering, 1998Contraction forces produced by single, human dermal fibroblasts (HDF), cultured on deformable silicone substrata, were quantified using video microscopy and image analysis. Cell contraction causes deformation of the substrate, which appears as a series of surface wrinkles perpendicular to the long axis of the cell.
T R, Fray +3 more
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Fibroblasts in Dermal Tissue Repair
International Journal of Dermatology, 1988ABSTRACT: The cellular dynamics of dermal regeneration were studied in nonsutured cutaneous wounds of female pigs and monkeys with electron microscopy and immunohistochemistry to demonstrate the origin and the development of fibroblasts forming granulation tissue. The results indicate that fibroblasts do not originate from histiocytes but from resting
H, Bouissou +4 more
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Contractility of single human dermal myofibroblasts and fibroblasts
Cell Motility, 2002AbstractHuman dermal myofibroblasts, characterised by the expression of α‐smooth muscle actin, are part of the granulation tissue and implicated in the generation of contractile forces during normal wound healing and pathological contractures. We have compared the contractile properties of single human dermal fibroblasts and human dermal myofibroblasts
Louise K, Wrobel +5 more
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