Results 261 to 270 of about 272,773 (298)

Ultrastructure of dermal fibroblasts during development and aging: Relationship to in vitro senescence of dermal fibroblasts

Experimental Gerontology, 1991
One approach to understanding the relationship between in vitro cellular senescence and in vivo aging is to define the development and aging of cells in vivo and then to compare these in vivo properties with the in vitro behavior of the same cells.
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Fibroblasts and Dermal Gene Therapy: A Minireview

Human Gene Therapy, 2000
This review highlights our current understanding of the biology of, survival of, and transgene expression by genetically modified fibroblasts (GMFb) carrying stably integrated transgenes in vivo. Experimental data demonstrate that three elements will enhance expression by and survival of GMFb in vivo: a matrix scaffolding to take the place of the ...
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Epidermal Regulation of Dermal Fibroblast Activity

Plastic and Reconstructive Surgery, 1998
Although the association between delayed burn wound healing and subsequent hypertrophic scar formation is well-established, the mechanism for this relationship is unknown. Unhealed burn wounds lack an epidermis, suggesting a possible regulatory role for the epidermis in controlling dermal fibroblast matrix synthesis.
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Fibroblasts in Dermal Tissue Repair

International Journal of Dermatology, 1988
ABSTRACT: The cellular dynamics of dermal regeneration were studied in nonsutured cutaneous wounds of female pigs and monkeys with electron microscopy and immunohistochemistry to demonstrate the origin and the development of fibroblasts forming granulation tissue. The results indicate that fibroblasts do not originate from histiocytes but from resting
H, Bouissou, M, Pieraggi, M, Julian, D, Uhart, J, Kokolo   +4 more
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Stimulation of Human Dermal Fibroblasts with Interleukin 2

Journal of Burn Care & Rehabilitation, 1991
The role of soluble inflammatory mediators in the wound healing process is under investigation. Interleukin 2 (IL2), an immune modulator produced by T lymphocytes, was tested in vitro for its effects on human diploid fibroblasts. Human diploid fibroblasts (1.0 x 10(4)) were incubated for 24 hours in Alpha minimal essential media (Gibco Laboratories ...
A, Abdullah, R L, McCauley, D N, Herndon
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Quantification of Single Human Dermal Fibroblast Contraction

Tissue Engineering, 1998
Contraction forces produced by single, human dermal fibroblasts (HDF), cultured on deformable silicone substrata, were quantified using video microscopy and image analysis. Cell contraction causes deformation of the substrate, which appears as a series of surface wrinkles perpendicular to the long axis of the cell.
T R, Fray, J E, Molloy, M P, Armitage, J C, Sparrow   +3 more
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Characterization of Human Dermal Fibroblasts in Fabry Disease

Journal of Cellular Physiology, 2015
Fabry disease (FD) is a hereditary X‐linked metabolic lysosomal storage disorder due to insufficient amounts or a complete lack of the lysosomal enzyme α‐galactosidase A (α‐GalA). The loss of α‐GalA activity leads to an abnormal accumulation of globotriaosylcerami (Gb3) in lysosomes and other cellular components of different tissues and cell types ...
LAKOMA, JARMILA, LIGUORI, ROCCO, DONADIO, VINCENZO ANGELO, CAPRINI, MARCO   +3 more
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The Effect of Tissue Expansion on Dermal Fibroblast Contraction

Annals of Plastic Surgery, 1992
Tissue expansion alters the function of skin cells. We studied the effects of expansion on the contractile function of dermal fibroblasts using an in vitro model, the fibroblast-populated collagen lattice (FPCL). Spherical expanders were placed dorsally in 30 Sprague-Dawley rats; one-half were serially inflated.
B, Chang, R E, Tuchler, J W, Siebert, M T, Longaker, D A, Burd   +4 more
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Contractility of single human dermal myofibroblasts and fibroblasts

Cell Motility, 2002
AbstractHuman dermal myofibroblasts, characterised by the expression of α‐smooth muscle actin, are part of the granulation tissue and implicated in the generation of contractile forces during normal wound healing and pathological contractures. We have compared the contractile properties of single human dermal fibroblasts and human dermal myofibroblasts
Louise K, Wrobel, Tim R, Fray, Justin E, Molloy, Julian J, Adams, Mark P, Armitage, John C, Sparrow   +5 more
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Antiphotoaging effect of chitooligosaccharides on human dermal fibroblasts

Photodermatology, Photoimmunology & Photomedicine, 2012
SummaryBackground/PurposeIn the present study, the effect of 3–5 kDa chitooligosaccharide (COS) on homeostasis between the expression of collagen‐degrading matrix metalloproteinases (MMPs) and collagen synthesis was investigated using ultraviolet (UV)‐A irradiated dermal fibroblasts.MethodsUV protection imparted by 3–5 kDa COS was measured by examining
Jung-Ae, Kim, Byul-Nim, Ahn, Chang-Suk, Kong, Sung-Ha, Park, Byoung-Jun, Park, Se-Kwon, Kim   +5 more
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